| 2. Round | 15/09/2021 | NEC Nijmegen [Youth B] | - | AFC Ajax [Youth B] | 2:4 |  |
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| 3. Round | 18/09/2021 | FC Utrecht [Youth B] | - | AFC Ajax [Youth B] | 4:1 | ||||
| 4. Round | 25/09/2021 | AFC Ajax [Youth B] | - | sc Heerenveen [Youth B] | 2:1 | ||||
| 6. Round | 16/10/2021 | AFC Ajax [Youth B] | - | AZ Alkmaar [Youth B] | 1:3 | ||||
| 13. Round | 05/02/2022 | sc Heerenveen [Youth B] | - | AFC Ajax [Youth B] | 1:1 | ||||
| 14. Round | 16/02/2022 | AFC Ajax [Youth B] | - | PEC Zwolle [Youth B] | 4:1 | ||||
| 11. Round | 19/02/2022 | AFC Ajax [Youth B] | - | NEC Nijmegen [Youth B] | 4:0 |
Netherlands