| 2. Round | 11/02/2017 | Guaraní | - | Sol de América | 2:1 |  |
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| 3. Round | 17/02/2017 | General Díaz | - | Guaraní | 1:2 | |
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| 4. Round | 26/02/2017 | Guaraní | - | Club Olimpia | 3:3 |  |
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| 6. Round | 11/03/2017 | Guaraní | - | Independiente CG | 3:2 | ||||
| 8. Round | 27/03/2017 | Deportivo Capiatá | - | Guaraní | 1:0 | ||||
| 10. Round | 02/04/2017 | Club Rubio Ñu | - | Guaraní | 1:2 | ||||
| 12. Round | 16/04/2017 | Guaraní | - | Libertad | 2:1 | |
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| 13. Round | 24/04/2017 | Sol de América | - | Guaraní | 2:2 | |
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| 17. Round | 21/05/2017 | Independiente CG | - | Guaraní | 4:2 | ||||
| 20. Round | 11/06/2017 | Cerro Porteño | - | Guaraní | 0:4 | ||||
| 21. Round | 18/06/2017 | Guaraní | - | Club Rubio Ñu | 2:1 |
Paraguay