1. Round | 06/01/2013 | Club San Luis | - | Santos Laguna | 1:1 | ||||
2. Round | 12/01/2013 | Santos Laguna | - | Deportivo Guadalajara | 2:0 | ||||
3. Round | 20/01/2013 | Puebla FC | - | Santos Laguna | 2:1 | ||||
4. Round | 26/01/2013 | Santos Laguna | - | Club León | 2:0 | ||||
5. Round | 03/02/2013 | Pumas UNAM | - | Santos Laguna | 0:0 | ||||
8. Round | 23/02/2013 | Santos Laguna | - | CF América | 1:0 | ||||
9. Round | 02/03/2013 | Jaguares Chiapas | - | Santos Laguna | 1:3 | ||||
10. Round | 10/03/2013 | Santos Laguna | - | Atlante | 2:1 | ||||
12. Round | 31/03/2013 | Santos Laguna | - | Gallos Blancos (old) | 1:1 | ||||
14. Round | 13/04/2013 | Santos Laguna | - | Deportivo Toluca | 2:1 | ||||
15. Round | 20/04/2013 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
17. Round | 05/05/2013 | Santos Laguna | - | Monarcas Morelia | 1:2 |