| 20. Round | 28/11/1980 | Manchester United | - | Southampton FC | 1:1 | ||||
| 21. Round | 05/12/1980 | Southampton FC | - | Coventry City | 1:0 | ||||
| 22. Round | 12/12/1980 | Wolverhampton Wanderers | - | Southampton FC | 1:1 | ||||
| 24. Round | 25/12/1980 | Tottenham Hotspur | - | Southampton FC | 4:4 | ||||
| 25. Round | 26/12/1980 | Southampton FC | - | Leicester City | 4:0 | ||||
| 27. Round | 16/01/1981 | Birmingham City | - | Southampton FC | 0:3 |
England