| 4. Round | 31/07/2022 | Libertad | - | Resistencia SC | 4:0 | ||||
| 5. Round | 06/08/2022 | 12 de Octubre de Itauguá | - | Libertad | 1:3 | ||||
| 6. Round | 13/08/2022 | Libertad | - | Sol de América | 4:1 | ||||
| 7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | ||||
| 14. Round | 02/10/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
| 16. Round | 09/10/2022 | Libertad | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 | ||||
| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |
Paraguay