1. Round 15/08/2021 UD Las Palmas - Real Valladolid 1:1
2. Round 20/08/2021 Real Valladolid - Real Zaragoza 2:0
3. Round 29/08/2021 CD Lugo - Real Valladolid 0:2 Goal red card
5. Round 12/09/2021 Real Valladolid - CD Tenerife 0:2
6. Round 18/09/2021 Girona FC - Real Valladolid 1:0
7. Round 26/09/2021 Real Valladolid - AD Alcorcón 2:0 Goal
8. Round 01/10/2021 SD Ponferradina - Real Valladolid 2:2 Goal
10. Round 17/10/2021 CD Leganés - Real Valladolid 0:2 Goal
11. Round 20/10/2021 Real Valladolid - UD Ibiza 1:1 Goal yellow card
12. Round 23/10/2021 Sporting Gijón - Real Valladolid 1:2
13. Round 31/10/2021 Real Valladolid - SD Eibar 2:0
14. Round 03/11/2021 SD Amorebieta - Real Valladolid 4:1
15. Round 06/11/2021 Real Valladolid - CD Mirandés 3:1 GoalGoal
17. Round 20/11/2021 UD Almería - Real Valladolid 3:1
18. Round 27/11/2021 Real Valladolid - FC Cartagena 2:0 Goal
19. Round 03/12/2021 SD Huesca - Real Valladolid 3:2
20. Round 12/12/2021 Real Valladolid - Real Oviedo 2:1 Goal yellow card
21. Round 19/12/2021 Real Sociedad B - Real Valladolid 0:2 Goal
22. Round 02/01/2022 Real Valladolid - CD Leganés 1:0 Goal
23. Round 08/01/2022 Real Valladolid - Burgos CF 1:0
24. Round 22/01/2022 Real Zaragoza - Real Valladolid 0:0
25. Round 28/01/2022 Real Valladolid - Sporting Gijón 1:0
26. Round 06/02/2022 CF Fuenlabrada - Real Valladolid 0:0
27. Round 12/02/2022 Real Valladolid - Girona FC 2:2
28. Round 18/02/2022 FC Cartagena - Real Valladolid 2:3 Goal
29. Round 27/02/2022 Real Valladolid - SD Amorebieta 5:1 Goal
31. Round 13/03/2022 Real Oviedo - Real Valladolid 3:0
32. Round 19/03/2022 Real Valladolid - UD Las Palmas 0:1 yellow card
33. Round 27/03/2022 AD Alcorcón - Real Valladolid 1:2
34. Round 02/04/2022 Real Valladolid - CD Lugo 4:1 Goal
35. Round 09/04/2022 Málaga CF - Real Valladolid 2:2 GoalGoal
36. Round 16/04/2022 Real Valladolid - UD Almería 2:2
37. Round 24/04/2022 CD Mirandés - Real Valladolid 0:1
38. Round 02/05/2022 Real Valladolid - Real Sociedad B 1:2
39. Round 08/05/2022 SD Eibar - Real Valladolid 0:2 Goal
40. Round 14/05/2022 Real Valladolid - SD Ponferradina 2:0
41. Round 21/05/2022 UD Ibiza - Real Valladolid 1:2 GoalGoal
42. Round 29/05/2022 Real Valladolid - SD Huesca 3:0 Goal