1st(1st leg) Spartak Moskva - AFC Ajax 0:3 (0:1)
2nd (2nd leg) AFC Ajax - Spartak Moskva 2:1 (1:0)
1st(1st leg): 04/11/2015 10:00 2nd (2nd leg): 25/11/2015 17:30 Winner: AFC Ajax
1st(1st leg) Beşiktaş - RB Salzburg 1:0 (0:0)
2nd (2nd leg) RB Salzburg - Beşiktaş 5:1 (1:1)
1st(1st leg): 04/11/2015 11:00 2nd (2nd leg): 24/11/2015 17:00 Winner: RB Salzburg
1st(1st leg) FK Rad Beograd - IF Elfsborg 0:1 (0:0)
2nd (2nd leg) IF Elfsborg - FK Rad Beograd 0:0 (0:0)
1st(1st leg): 04/11/2015 13:00 2nd (2nd leg): 25/11/2015 17:00 Winner: IF Elfsborg
1st(1st leg) 1. FK Příbram - FC Viitorul Constanța 2:0 (1:0)
2nd (2nd leg) FC Viitorul Constanța - 1. FK Příbram 0:0 (0:0)
1st(1st leg): 04/11/2015 16:00 2nd (2nd leg): 25/11/2015 16:00 Winner: 1. FK Příbram
1st(1st leg) Puskás FC - Celtic FC 1:0 (0:0)
2nd (2nd leg) Celtic FC - Puskás FC 3:0 (2:0)
1st(1st leg): 04/11/2015 17:00 2nd (2nd leg): 25/11/2015 19:00 Winner: Celtic FC
1st(1st leg) FC Midtjylland - Legia Warszawa 2:0 (0:0)
2nd (2nd leg) Legia Warszawa - FC Midtjylland 1:3 (0:1)
1st(1st leg): 04/11/2015 17:00 2nd (2nd leg): 24/11/2015 15:00 Winner: FC Midtjylland
1st(1st leg) Middlesbrough FC - Torino FC 3:0 (0:0)
2nd (2nd leg) Torino FC - Middlesbrough FC 3:3 (0:0)
1st(1st leg): 05/11/2015 19:00 2nd (2nd leg): 24/11/2015 19:00 Winner: Middlesbrough FC
1st(1st leg) Servette FC - RSC Anderlecht 1:2 (0:0)
2nd (2nd leg) RSC Anderlecht - Servette FC 2:2 (1:2)
1st(1st leg): 02/12/2015 13:00 2nd (2nd leg): 06/12/2015 13:00 Winner: RSC Anderlecht