1st(1st leg) PAOK Saloniki - AFC Ajax 0:2 (0:1)
2nd (2nd leg) AFC Ajax - PAOK Saloniki 2:1 (0:0)
1st(1st leg): 02/11/2016 13:00 2nd (2nd leg): 22/11/2016 18:00 Winner: AFC Ajax
1st(1st leg) FC Viitorul Constanța - FC Zürich 5:0 (2:0)
2nd (2nd leg) FC Zürich - FC Viitorul Constanța 2:0 (2:0)
1st(1st leg): 02/11/2016 16:00 2nd (2nd leg): 23/11/2016 16:00 Winner: FC Viitorul Constanța
1st(1st leg) Málaga CF - FC Midtjylland 2:0 (0:0)
2nd (2nd leg) FC Midtjylland - Málaga CF 4:0 (2:0)
1st(1st leg): 02/11/2016 17:00 2nd (2nd leg): 23/11/2016 18:00 Winner: FC Midtjylland
1st(1st leg) Rosenborg BK - FK Čukarički 0:1 (0:0)
2nd (2nd leg) FK Čukarički - Rosenborg BK 0:2 (0:0)
1st(1st leg): 02/11/2016 17:00 2nd (2nd leg): 23/11/2016 17:00 Winner: Rosenborg BK
1st(1st leg) RB Salzburg - FK Kairat 8:1 (2:0)
2nd (2nd leg) FK Kairat - RB Salzburg 0:1 (0:1)
1st(1st leg): 02/11/2016 17:00 2nd (2nd leg): 23/11/2016 13:00 Winner: RB Salzburg
1st(1st leg) Cork City - AS Roma 1:3 (1:1)
2nd (2nd leg) AS Roma - Cork City 1:0 (0:0)
1st(1st leg): 02/11/2016 19:00 2nd (2nd leg): 23/11/2016 14:00 Winner: AS Roma
1st(1st leg) Altınordu FK - AC Sparta Praha 6:2 (3:1)
2nd (2nd leg) AC Sparta Praha - Altınordu FK 3:2 (0:1)
1st(1st leg): 09/11/2016 13:00 2nd (2nd leg): 30/11/2016 14:00 Winner: Altınordu FK
1st(1st leg) Maccabi Haifa - Dinamo Moskva 0:0 (0:0)
2nd (2nd leg) Dinamo Moskva - Maccabi Haifa 1:1 (0:0)
1st(1st leg): 16/11/2016 15:00 2nd (2nd leg): 23/11/2016 10:30 Winner: Maccabi Haifa