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| 1st(1st leg) | RSC Anderlecht | - | Dinamo Kiev | 1:1 (1:0) | ||
| 2nd (2nd leg) | Dinamo Kiev | - | RSC Anderlecht | 2:1 (0:0) | ||
| 1st(1st leg): 06/11/2018 18:30 | 2nd (2nd leg): 27/11/2018 15:00 | Winner: Dinamo Kiev | ||||
| 1st(1st leg) | FK Astana | - | Dinamo Zagreb | 1:1 (1:0) | ||
| 2nd (2nd leg) | Dinamo Zagreb | - | FK Astana | 3:1 (2:0) | ||
| 1st(1st leg): 07/11/2018 05:00 | 2nd (2nd leg): 27/11/2018 12:30 | Winner: Dinamo Zagreb | ||||
| 1st(1st leg) | Gabala FK | - | Hertha BSC | 1:3 (0:0) | ||
| 2nd (2nd leg) | Hertha BSC | - | Gabala FK | 1:0 (1:0) | ||
| 1st(1st leg): 07/11/2018 13:00 | 2nd (2nd leg): 28/11/2018 12:00 | Winner: Hertha BSC | ||||
| 1st(1st leg) | Altınordu FK | - | Montpellier HSC | 2:4 (1:2) | ||
| 2nd (2nd leg) | Montpellier HSC | - | Altınordu FK | 1:0 (0:0) | ||
| 1st(1st leg): 07/11/2018 15:00 | 2nd (2nd leg): 28/11/2018 14:00 | Winner: Montpellier HSC | ||||
| 1st(1st leg) | PAOK Saloniki | - | FK Minsk | 2:1 (1:1) | ||
| 2nd (2nd leg) | FK Minsk | - | PAOK Saloniki | 0:1 (0:0) | ||
| 1st(1st leg): 07/11/2018 15:00 | 2nd (2nd leg): 28/11/2018 11:00 | Winner: PAOK Saloniki | ||||
| 1st(1st leg) | Sigma Olomouc | - | Maccabi Tel Aviv | 1:1 (0:0) | ||
| 2nd (2nd leg) | Maccabi Tel Aviv | - | Sigma Olomouc | 2:2 (0:0) | ||
| 1st(1st leg): 07/11/2018 15:00 | 2nd (2nd leg): 28/11/2018 15:00 | Winner: Sigma Olomouc | ||||
| 1st(1st leg) | IF Elfsborg | - | Chelsea FC | 0:3 (0:1) | ||
| 2nd (2nd leg) | Chelsea FC | - | IF Elfsborg | 6:0 (4:0) | ||
| 1st(1st leg): 07/11/2018 17:00 | 2nd (2nd leg): 28/11/2018 13:00 | Winner: Chelsea FC | ||||
| 1st(1st leg) | FC Midtjylland | - | Hamilton Academical | 2:0 (2:0) | ||
| 2nd (2nd leg) | Hamilton Academical | - | FC Midtjylland | 1:2 (1:0) | ||
| 1st(1st leg): 07/11/2018 17:30 | 2nd (2nd leg): 28/11/2018 19:00 | Winner: FC Midtjylland | ||||
