1st(1st leg) FC Midtjylland - Zrinjski Mostar 3:1 (1:0)
2nd (2nd leg) Zrinjski Mostar - FC Midtjylland 0:0 (0:0)
1st(1st leg): 04/11/2019 13:00 2nd (2nd leg): 26/11/2019 12:30 Winner: FC Midtjylland
1st(1st leg) FC Porto - NK Domžale 2:2 (0:0)
2nd (2nd leg) NK Domžale - FC Porto 0:3 (0:1)
1st(1st leg): 06/11/2019 15:00 2nd (2nd leg): 27/11/2019 16:00 Winner: FC Porto
1st(1st leg) Dinamo Kiev - PAOK Saloniki 3:0 (2:0)
2nd (2nd leg) PAOK Saloniki - Dinamo Kiev 2:2 (2:0)
1st(1st leg): 06/11/2019 15:00 2nd (2nd leg): 27/11/2019 15:00 Winner: Dinamo Kiev
1st(1st leg) FC Sheriff - Sogndal IL 2:0 (1:0)
2nd (2nd leg) Sogndal IL - FC Sheriff 3:1 (2:0)
1st(1st leg): 06/11/2019 16:00 2nd (2nd leg): 27/11/2019 17:00 Winner: FC Sheriff
1st(1st leg) Real Zaragoza - APOEL Nikosia 5:0 (3:0)
2nd (2nd leg) APOEL Nikosia - Real Zaragoza 0:4 (0:3)
1st(1st leg): 06/11/2019 16:00 2nd (2nd leg): 27/11/2019 15:00 Winner: Real Zaragoza
1st(1st leg) Stade Rennais - Maccabi Petach-Tikva 2:0 (1:0)
2nd (2nd leg) Maccabi Petach-Tikva - Stade Rennais 0:1 (0:0)
1st(1st leg): 06/11/2019 17:00 2nd (2nd leg): 04/12/2019 13:00 Winner: Stade Rennais
1st(1st leg) ÍA Akranes - Derby County 1:2 (0:2)
2nd (2nd leg) Derby County - ÍA Akranes 4:1 (3:0)
1st(1st leg): 06/11/2019 19:00 2nd (2nd leg): 27/11/2019 19:00 Winner: Derby County
1st(1st leg) Rangers FC - Slovan Bratislava 2:0 (1:0)
2nd (2nd leg) Slovan Bratislava - Rangers FC 1:2 (1:1)
1st(1st leg): 06/11/2019 19:00 2nd (2nd leg): 27/11/2019 16:00 Winner: Rangers FC