1st(1st leg) Esteghlal - Al Sadd 1:3 (1:0)
2nd (2nd leg) Al Sadd - Esteghlal 2:2 (1:1)
1st(1st leg): 27/08/2018 17:00 2nd (2nd leg): 17/09/2018 17:00 Winner: Al Sadd
1st(1st leg) Kashima Antlers - Tianjin Quanjian FC 2:0 (0:0)
2nd (2nd leg) Tianjin Quanjian FC - Kashima Antlers 0:3 (0:2)
1st(1st leg): 28/08/2018 11:00 2nd (2nd leg): 18/09/2018 12:30 Winner: Kashima Antlers
1st(1st leg) Al Duhail SC - Persepolis 1:0 (1:0)
2nd (2nd leg) Persepolis - Al Duhail SC 3:1 (0:1)
1st(1st leg): 28/08/2018 16:30 2nd (2nd leg): 17/09/2018 15:00 Winner: Persepolis
1st(1st leg) Jeonbuk FC - Suwon Bluewings 0:3 (0:0)
2nd (2nd leg) Suwon Bluewings - Jeonbuk FC 4:2 (0:1, 0:3, 0:3) pso
1st(1st leg): 29/08/2018 11:00 2nd (2nd leg): 19/09/2018 11:00 Winner: Suwon Bluewings