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| 1st(1st leg) | Eritrea | - | Botswana | dnp | ||
| 2nd (2nd leg) | Botswana | - | Eritrea | dnp | ||
| 1st(1st leg): 21/03/2022 | 2nd (2nd leg): 29/03/2022 | Winner: Eritrea | ||||
| 1st(1st leg) | Seychelles | - | Lesotho | 0:0 (0:0) | ||
| 2nd (2nd leg) | Lesotho | - | Seychelles | 3:1 (2:1) | ||
| 1st(1st leg): 23/03/2022 12:00 | 2nd (2nd leg): 27/03/2022 15:00 | Winner: Lesotho | ||||
| 1st(1st leg) | Djibouti | - | South Sudan | 2:4 (0:0) | ||
| 2nd (2nd leg) | South Sudan | - | Djibouti | 1:0 (0:0) | ||
| 1st(1st leg): 23/03/2022 13:00 | 2nd (2nd leg): 27/03/2022 14:00 | Winner: South Sudan | ||||
| 1st(1st leg) | Somalia | - | Eswatini | 0:3 (0:1) | ||
| 2nd (2nd leg) | Eswatini | - | Somalia | 2:1 (0:0) | ||
| 1st(1st leg): 23/03/2022 13:00 | 2nd (2nd leg): 27/03/2022 14:00 | Winner: Eswatini | ||||
| 1st(1st leg) | Chad | - | Gambia | 0:1 (0:0) | ||
| 2nd (2nd leg) | Gambia | - | Chad | 2:2 (1:1) | ||
| 1st(1st leg): 23/03/2022 16:00 | 2nd (2nd leg): 29/03/2022 18:00 | Winner: Gambia | ||||
| 1st(1st leg) | São Tomé and Príncipe | - | Mauritius | 1:0 (1:0) | ||
| 2nd (2nd leg) | Mauritius | - | São Tomé and Príncipe | 3:3 (1:2) | ||
| 1st(1st leg): 24/03/2022 12:00 | 2nd (2nd leg): 27/03/2022 13:00 | Winner: São Tomé and Príncipe | ||||
