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| 1st(1st leg) | FK Partizani | - | KS Kamza | 0:1 | ||
| 2nd (2nd leg) | KS Kamza | - | FK Partizani | 0:0 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KS Kamza | ||||
| 1st(1st leg) | KS Pogradeci | - | KF Lushnja | 1:0 | ||
| 2nd (2nd leg) | KF Lushnja | - | KS Pogradeci | 4:1 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Lushnja | ||||
| 1st(1st leg) | Luftëtari Gjirokastër | - | KS Gramozi | 0:0 | ||
| 2nd (2nd leg) | KS Gramozi | - | Luftëtari Gjirokastër | 2:1 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KS Gramozi | ||||
| 1st(1st leg) | KF Ada Velipojë | - | KF Apolonia Fier | 2:1 | ||
| 2nd (2nd leg) | KF Apolonia Fier | - | KF Ada Velipojë | 0:0 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Ada Velipojë | ||||
| 1st(1st leg) | KS Burreli | - | KF Skënderbeu | 2:2 | ||
| 2nd (2nd leg) | KF Skënderbeu | - | KS Burreli | 2:1 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Skënderbeu | ||||
| 1st(1st leg) | KF Gramshi | - | KF Elbasani | 0:0 | ||
| 2nd (2nd leg) | KF Elbasani | - | KF Gramshi | 2:1 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Elbasani | ||||
| 1st(1st leg) | Skrapari Çorovodë | - | KF Tiranë | 0:1 | ||
| 2nd (2nd leg) | KF Tiranë | - | Skrapari Çorovodë | 4:0 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Tiranë | ||||
| 1st(1st leg) | Sopoti Librazhd | - | KS Besa | 0:3 | ||
| 2nd (2nd leg) | KS Besa | - | Sopoti Librazhd | 7:2 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KS Besa | ||||
| 1st(1st leg) | KS Besëlidhja Lezhë | - | KF Bylis Ballsh | 1:3 | ||
| 2nd (2nd leg) | KF Bylis Ballsh | - | KS Besëlidhja Lezhë | 4:0 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Bylis Ballsh | ||||
| 1st(1st leg) | KF Memaliaj | - | KF Laçi | 1:1 | ||
| 2nd (2nd leg) | KF Laçi | - | KF Memaliaj | 3:2 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Laçi | ||||
| 1st(1st leg) | KF Adriatiku Mamurrasi | - | KF Teuta Durrës | 2:3 | ||
| 2nd (2nd leg) | KF Teuta Durrës | - | KF Adriatiku Mamurrasi | 1:1 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KF Teuta Durrës | ||||
| 1st(1st leg) | FK Tomori Berat | - | Flamurtari Vlorë | 0:0 | ||
| 2nd (2nd leg) | Flamurtari Vlorë | - | FK Tomori Berat | 4:2 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: Flamurtari Vlorë | ||||
| 1st(1st leg) | KF Tërbuni Pukë | - | FK Vllaznia | 1:1 | ||
| 2nd (2nd leg) | FK Vllaznia | - | KF Tërbuni Pukë | 5:0 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: FK Vllaznia | ||||
| 1st(1st leg) | KF Luz i Vogël 2008 | - | Dinamo Tiranë | 0:3 | ||
| 2nd (2nd leg) | Dinamo Tiranë | - | KF Luz i Vogël 2008 | 7:2 | ||
| 1st(1st leg): 20/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: Dinamo Tiranë | ||||
| 1st(1st leg) | KF Bilisht | - | KS Kastrioti | 2:2 | ||
| 2nd (2nd leg) | KS Kastrioti | - | KF Bilisht | 2:0 | ||
| 1st(1st leg): 26/10/2010 13:30 | 2nd (2nd leg): 03/11/2010 12:30 | Winner: KS Kastrioti | ||||
