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| 1st(1st leg) | Flamurtari Vlorë | - | FK Vllaznia | 1:2 | ||
| 2nd (2nd leg) | FK Vllaznia | - | Flamurtari Vlorë | 1:0 | ||
| 1st(1st leg): 26/01/2022 12:45 | 2nd (2nd leg): 10/02/2022 12:45 | Winner: FK Vllaznia | ||||
| 1st(1st leg) | Egnatia Rrogozhine | - | KF Laçi | 1:1 | ||
| 2nd (2nd leg) | KF Laçi | - | Egnatia Rrogozhine | 3:2 pso | ||
| 1st(1st leg): 26/01/2022 12:45 | 2nd (2nd leg): 10/02/2022 12:45 | Winner: KF Laçi | ||||
| 1st(1st leg) | KF Skënderbeu | - | KF Teuta Durrës | 0:1 | ||
| 2nd (2nd leg) | KF Teuta Durrës | - | KF Skënderbeu | 1:0 (1:0) | ||
| 1st(1st leg): 27/01/2022 13:25 | 2nd (2nd leg): 09/02/2022 15:45 | Winner: KF Teuta Durrës | ||||
| 1st(1st leg) | Dinamo Tiranë | - | FK Partizani | 1:1 | ||
| 2nd (2nd leg) | FK Partizani | - | Dinamo Tiranë | 1:0 | ||
| 1st(1st leg): 27/01/2022 15:45 | 2nd (2nd leg): 10/02/2022 17:00 | Winner: FK Partizani | ||||
