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| 19/04/2022 | 18:00 | Arsenal de Sarandí | - | Barracas Central | 0:1 (0:1) | |
| 20:30 | Unión de Santa Fe | - | San Lorenzo | 1:2 (0:1) | ||
| 23:00 | Huracán | - | Colón de Santa Fe | 1:1 (1:1) | ||
| 23:00 | Estudiantes | - | Tigre | 2:1 (0:0) | ||
| 20/04/2022 | 01:30 | Platense | - | Gimnasia de La Plata | 0:3 (0:2) | |
| 01:30 | Independiente | - | Aldosivi | 1:1 (1:1) | ||
| 18:00 | Newell's Old Boys | - | Banfield | 1:0 (0:0) | ||
| 20:30 | Patronato de Paraná | - | Racing Club | 2:3 (1:2) | ||
| 20:30 | Vélez Sarsfield | - | Central Córdoba SdE | 1:2 (1:0) | ||
| 23:00 | Talleres de Córdoba | - | River Plate | 1:0 (0:0) | ||
| 23:00 | Lanús | - | Rosario Central | 3:1 (1:0) | ||
| 21/04/2022 | 01:30 | Boca Juniors | - | Godoy Cruz | 1:1 (1:1) | |
| 20:00 | Sarmiento de Junín | - | Defensa y Justicia | 2:1 (2:1) | ||
| 22:30 | Atlético Tucumán | - | Argentinos Juniors | 2:4 (1:2) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| 1 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing Club | 11 | 8 | 3 | 0 | 23:8 | 15 | 27 |
| 2 |
|
River Plate | 11 | 7 | 1 | 3 | 21:10 | 11 | 22 |
| 3 |
|
Newell's Old Boys | 11 | 7 | 1 | 3 | 15:10 | 5 | 22 |
| 4 |
|
Argentinos Juniors | 11 | 6 | 2 | 3 | 18:14 | 4 | 20 |
| 5 |
|
Sarmiento de Junín | 11 | 6 | 2 | 3 | 17:16 | 1 | 20 |
| 6 |
|
Defensa y Justicia | 11 | 5 | 3 | 3 | 22:17 | 5 | 18 |
| 7 |
|
Unión de Santa Fe | 11 | 5 | 2 | 4 | 9:8 | 1 | 17 |
| 8 |
|
Gimnasia de La Plata | 11 | 4 | 3 | 4 | 14:19 | -5 | 15 |
| 9 |
|
Banfield | 11 | 4 | 2 | 5 | 13:12 | 1 | 14 |
| 10 |
|
San Lorenzo | 11 | 2 | 5 | 4 | 11:13 | -2 | 11 |
| 11 |
|
Talleres de Córdoba | 11 | 2 | 2 | 7 | 7:15 | -8 | 8 |
| 12 |
|
Platense | 11 | 2 | 2 | 7 | 9:19 | -10 | 8 |
| 13 |
|
Patronato de Paraná | 11 | 2 | 1 | 8 | 8:17 | -9 | 7 |
| 14 |
|
Atlético Tucumán | 11 | 1 | 3 | 7 | 8:21 | -13 | 6 |
| 2 | |||||||||
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes | 11 | 7 | 3 | 1 | 28:14 | 14 | 24 |
| 2 |
|
Aldosivi | 11 | 6 | 2 | 3 | 15:10 | 5 | 20 |
| 3 |
|
Tigre | 11 | 5 | 4 | 2 | 15:7 | 8 | 19 |
| 4 |
|
Boca Juniors | 11 | 4 | 6 | 1 | 13:10 | 3 | 18 |
| 5 |
|
Colón de Santa Fe | 11 | 3 | 6 | 2 | 15:13 | 2 | 15 |
| 6 |
|
Barracas Central | 11 | 5 | 0 | 6 | 13:20 | -7 | 15 |
| 7 |
|
Central Córdoba SdE | 11 | 3 | 5 | 3 | 13:17 | -4 | 14 |
| 8 |
|
Independiente | 11 | 2 | 7 | 2 | 14:14 | 0 | 13 |
| 9 |
|
Godoy Cruz | 11 | 2 | 6 | 3 | 18:20 | -2 | 12 |
| 10 |
|
Huracán | 11 | 3 | 3 | 5 | 13:15 | -2 | 12 |
| 11 |
|
Vélez Sarsfield | 11 | 2 | 5 | 4 | 7:8 | -1 | 11 |
| 12 |
|
Arsenal de Sarandí | 11 | 1 | 7 | 3 | 16:18 | -2 | 10 |
| 13 |
|
Lanús | 11 | 2 | 4 | 5 | 12:14 | -2 | 10 |
| 14 |
|
Rosario Central | 11 | 2 | 2 | 7 | 9:17 | -8 | 8 |
| Playoffs | |
| Playoffs |
