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| 1st(1st leg) | CA Los Andes | - | Colegiales de Munro | 1:0 (1:0) | ||
| 2nd (2nd leg) | Colegiales de Munro | - | CA Los Andes | 3:1 (0:0, 1:0) pso | ||
| 1st(1st leg): 27/11/2021 20:00 | 2nd (2nd leg): 05/12/2021 20:00 | Winner: Colegiales de Munro | ||||
| 1st(1st leg) | Justo José de Urquiza | - | Sacachispas | 1:1 (1:0) | ||
| 2nd (2nd leg) | Sacachispas | - | Justo José de Urquiza | 1:0 (1:0) | ||
| 1st(1st leg): 27/11/2021 20:00 | 2nd (2nd leg): 05/12/2021 20:00 | Winner: Sacachispas | ||||
