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| 23/04/2022 | 01:10 | San Martín de Tucumán | - | Mitre de SdE | 0:4 (0:3) | |
| 19:00 | Brown de Adrogué | - | Independiente Rivadavia | 1:1 (0:0) | ||
| 19:30 | Atlanta | - | Estudiantes de Río Cuarto | 0:0 (0:0) | ||
| 19:30 | San Telmo | - | Temperley | 3:1 (1:0) | ||
| 20:10 | Chacarita Juniors | - | Quilmes | 2:2 (0:1) | ||
| 20:30 | San Martín de San Juan | - | Deportivo Madryn | 3:2 (1:2) | ||
| 23:00 | Tristan Suárez | - | Sacachispas | 2:1 (2:0) | ||
| 23:45 | Ramón Santamarina | - | Almagro | 0:0 (0:0) | ||
| 24/04/2022 | 00:10 | All Boys | - | Gimnasia de Jujuy | 2:0 (2:0) | |
| 01:00 | Chaco For Ever | - | Deportivo Morón | 1:0 (1:0) | ||
| 18:10 | Atlético Rafaela | - | Nueva Chicago | 1:1 (0:1) | ||
| 19:00 | Estudiantes de Caseros | - | Alvarado | 2:0 (1:0) | ||
| 19:30 | Guillermo Brown | - | Deportivo Maipú | 0:1 (0:1) | ||
| 23:00 | Güemes de SdE | - | Almirante Brown | 2:1 (1:1) | ||
| 25/04/2022 | 19:30 | Deportivo Riestra | - | Villa Dálmine | 1:1 (1:0) | |
| 19:35 | Agropecuario Argentino | - | Instituto de Córdoba | 2:0 (1:0) | ||
| 23:10 | Gimnasia de Mendoza | - | Flandria | 2:1 (0:1) | ||
| 26/04/2022 | 01:10 | Defensores de Belgrano | - | Ferro Carril Oeste | 2:2 (2:2) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 11 | 9 | 1 | 1 | 17:8 | 9 | 28 |
| 2 |
|
San Martín de Tucumán | 12 | 7 | 3 | 2 | 18:12 | 6 | 24 |
| 3 |
|
Brown de Adrogué | 12 | 5 | 6 | 1 | 18:10 | 8 | 21 |
| 4 |
|
Deportivo Maipú | 12 | 5 | 5 | 2 | 13:10 | 3 | 20 |
| 5 |
|
Instituto de Córdoba | 11 | 5 | 5 | 1 | 12:9 | 3 | 20 |
| 6 |
|
Chacarita Juniors | 12 | 5 | 4 | 3 | 21:16 | 5 | 19 |
| 7 |
|
Gimnasia de Mendoza | 11 | 5 | 3 | 3 | 16:7 | 9 | 18 |
| 8 |
|
All Boys | 11 | 4 | 6 | 1 | 16:11 | 5 | 18 |
| 9 |
|
Chaco For Ever | 12 | 3 | 9 | 0 | 12:8 | 4 | 18 |
| 10 |
|
Deportivo Riestra | 11 | 4 | 6 | 1 | 9:5 | 4 | 18 |
| 11 |
|
Estudiantes de Río Cuarto | 12 | 4 | 6 | 2 | 10:9 | 1 | 18 |
| 12 |
|
Deportivo Madryn | 12 | 4 | 5 | 3 | 16:12 | 4 | 17 |
| 13 |
|
Agropecuario Argentino | 12 | 4 | 5 | 3 | 13:9 | 4 | 17 |
| 14 |
|
San Martín de San Juan | 12 | 5 | 2 | 5 | 16:13 | 3 | 17 |
| 15 |
|
Estudiantes de Caseros | 12 | 4 | 5 | 3 | 11:9 | 2 | 17 |
| 16 |
|
Almirante Brown | 12 | 4 | 5 | 3 | 15:14 | 1 | 17 |
| 17 |
|
Guillermo Brown | 12 | 5 | 2 | 5 | 11:11 | 0 | 17 |
| 18 |
|
Almagro | 12 | 5 | 2 | 5 | 11:14 | -3 | 17 |
| 19 |
|
Defensores de Belgrano | 12 | 4 | 4 | 4 | 14:16 | -2 | 16 |
| 20 |
|
Atlanta | 12 | 3 | 6 | 3 | 13:12 | 1 | 15 |
| 21 |
|
Independiente Rivadavia | 11 | 4 | 3 | 4 | 12:13 | -1 | 15 |
| 22 |
|
Quilmes | 11 | 2 | 7 | 2 | 14:13 | 1 | 13 |
| 23 |
|
Atlético Rafaela | 12 | 3 | 4 | 5 | 13:12 | 1 | 13 |
| 24 |
|
Nueva Chicago | 12 | 2 | 7 | 3 | 12:14 | -2 | 13 |
| 25 |
|
Alvarado | 12 | 3 | 4 | 5 | 13:20 | -7 | 13 |
| 26 |
|
Deportivo Morón | 12 | 2 | 6 | 4 | 6:7 | -1 | 12 |
| 27 |
|
San Telmo | 11 | 2 | 6 | 3 | 11:17 | -6 | 12 |
| 28 |
|
Gimnasia de Jujuy | 12 | 2 | 5 | 5 | 9:18 | -9 | 11 |
| 29 |
|
Sacachispas | 11 | 1 | 7 | 3 | 10:11 | -1 | 10 |
| 30 |
|
Mitre de SdE | 11 | 2 | 4 | 5 | 11:13 | -2 | 10 |
| 31 |
|
Tristan Suárez | 12 | 1 | 7 | 4 | 15:18 | -3 | 10 |
| 32 |
|
Flandria | 12 | 2 | 4 | 6 | 17:21 | -4 | 10 |
| 33 |
|
Villa Dálmine | 12 | 1 | 7 | 4 | 12:20 | -8 | 10 |
| 34 |
|
Ferro Carril Oeste | 11 | 1 | 6 | 4 | 11:16 | -5 | 9 |
| 35 |
|
Temperley | 12 | 2 | 3 | 7 | 10:17 | -7 | 9 |
| 36 |
|
Güemes de SdE | 11 | 1 | 5 | 5 | 6:12 | -6 | 8 |
| 37 |
|
Ramón Santamarina | 12 | 1 | 5 | 6 | 10:17 | -7 | 8 |
| Promotion | |
| Playoffs | |
| Playoffs | |
| Relegation |
