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| 06/08/2022 | 00:10 | Deportivo Morón | - | Almagro | 3:0 (2:0) | |
| 17:10 | San Telmo | - | San Martín de Tucumán | 1:0 (0:0) | ||
| 19:00 | Gimnasia de Mendoza | - | Tristan Suárez | 0:0 (0:0) | ||
| 19:30 | Deportivo Riestra | - | Sacachispas | 2:0 (2:0) | ||
| 19:30 | Villa Dálmine | - | Ferro Carril Oeste | 1:0 (1:0) | ||
| 20:40 | Estudiantes de Caseros | - | Guillermo Brown | 3:2 (2:1) | ||
| 22:05 | Temperley | - | Nueva Chicago | 2:2 (2:0) | ||
| 07/08/2022 | 19:00 | Deportivo Madryn | - | Alvarado | 1:1 (0:0) | |
| 19:00 | Flandria | - | Deportivo Maipú | 1:1 (0:0) | ||
| 19:15 | All Boys | - | Agropecuario Argentino | 0:0 (0:0) | ||
| 20:00 | Ramón Santamarina | - | Atlético Rafaela | 3:1 (1:0) | ||
| 20:30 | Chaco For Ever | - | Defensores de Belgrano | 1:0 (0:0) | ||
| 08/08/2022 | 00:00 | Belgrano de Córdoba | - | Mitre de SdE | 1:3 (0:2) | |
| 19:00 | Gimnasia de Jujuy | - | Quilmes | 3:1 (1:1) | ||
| 19:30 | San Martín de San Juan | - | Brown de Adrogué | 3:2 (2:0) | ||
| 21:10 | Güemes de SdE | - | Instituto de Córdoba | 1:1 (1:0) | ||
| 09/08/2022 | 01:10 | Atlanta | - | Chacarita Juniors | 1:1 (0:0) | |
| 10/08/2022 | 01:10 | Almirante Brown | - | Independiente Rivadavia | 2:0 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 27 | 17 | 6 | 4 | 31:18 | 13 | 57 |
| 2 |
|
Instituto de Córdoba | 27 | 14 | 9 | 4 | 34:19 | 15 | 51 |
| 3 |
|
San Martín de Tucumán | 27 | 13 | 11 | 3 | 32:16 | 16 | 50 |
| 4 |
|
Gimnasia de Mendoza | 27 | 12 | 11 | 4 | 31:12 | 19 | 47 |
| 5 |
|
All Boys | 27 | 11 | 13 | 3 | 37:22 | 15 | 46 |
| 6 |
|
Almagro | 28 | 12 | 7 | 9 | 27:26 | 1 | 43 |
| 7 |
|
Estudiantes de Río Cuarto | 27 | 10 | 12 | 5 | 31:26 | 5 | 42 |
| 8 |
|
Defensores de Belgrano | 27 | 10 | 11 | 6 | 30:22 | 8 | 41 |
| 9 |
|
Chaco For Ever | 28 | 9 | 14 | 5 | 28:20 | 8 | 41 |
| 10 |
|
San Martín de San Juan | 28 | 12 | 5 | 11 | 38:32 | 6 | 41 |
| 11 |
|
Estudiantes de Caseros | 28 | 11 | 8 | 9 | 25:24 | 1 | 41 |
| 12 |
|
Deportivo Riestra | 27 | 9 | 13 | 5 | 26:21 | 5 | 40 |
| 13 |
|
Independiente Rivadavia | 27 | 10 | 9 | 8 | 33:26 | 7 | 39 |
| 14 |
|
Deportivo Maipú | 28 | 8 | 14 | 6 | 33:25 | 8 | 38 |
| 15 |
|
Brown de Adrogué | 27 | 10 | 8 | 9 | 32:28 | 4 | 38 |
| 16 |
|
Deportivo Madryn | 27 | 8 | 13 | 6 | 35:28 | 7 | 37 |
| 17 |
|
Chacarita Juniors | 27 | 9 | 9 | 9 | 38:34 | 4 | 36 |
| 18 |
|
Deportivo Morón | 27 | 7 | 14 | 6 | 21:16 | 5 | 35 |
| 19 |
|
Gimnasia de Jujuy | 27 | 9 | 8 | 10 | 30:35 | -5 | 35 |
| 20 |
|
Guillermo Brown | 27 | 10 | 5 | 12 | 24:30 | -6 | 35 |
| 21 |
|
Güemes de SdE | 27 | 8 | 10 | 9 | 23:21 | 2 | 34 |
| 22 |
|
Mitre de SdE | 27 | 8 | 9 | 10 | 29:30 | -1 | 33 |
| 23 |
|
Almirante Brown | 27 | 7 | 12 | 8 | 30:33 | -3 | 33 |
| 24 |
|
Ferro Carril Oeste | 27 | 8 | 9 | 10 | 22:27 | -5 | 33 |
| 25 |
|
Agropecuario Argentino | 27 | 6 | 14 | 7 | 22:23 | -1 | 32 |
| 26 |
|
Quilmes | 27 | 7 | 10 | 10 | 31:35 | -4 | 31 |
| 27 |
|
Atlanta | 28 | 6 | 12 | 10 | 22:27 | -5 | 30 |
| 28 |
|
San Telmo | 27 | 7 | 9 | 11 | 26:39 | -13 | 30 |
| 29 |
|
Temperley | 27 | 5 | 13 | 9 | 23:31 | -8 | 28 |
| 30 |
|
Alvarado | 28 | 6 | 10 | 12 | 26:42 | -16 | 28 |
| 31 |
|
Villa Dálmine | 27 | 5 | 12 | 10 | 30:43 | -13 | 27 |
| 32 |
|
Atlético Rafaela | 27 | 5 | 11 | 11 | 28:34 | -6 | 26 |
| 33 |
|
Nueva Chicago | 28 | 5 | 11 | 12 | 28:40 | -12 | 26 |
| 34 |
|
Flandria | 27 | 5 | 10 | 12 | 27:37 | -10 | 25 |
| 35 |
|
Tristan Suárez | 27 | 5 | 9 | 13 | 27:33 | -6 | 24 |
| 36 |
|
Ramón Santamarina | 28 | 5 | 9 | 14 | 21:43 | -22 | 24 |
| 37 |
|
Sacachispas | 27 | 3 | 14 | 10 | 18:31 | -13 | 23 |
| Promotion | |
| Playoffs | |
| Playoffs | |
| Relegation |
