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| 12/08/2022 | 22:35 | Atlético Rafaela | - | Estudiantes de Caseros | 1:2 (0:1) | |
| 13/08/2022 | 18:10 | Sacachispas | - | Belgrano de Córdoba | 1:1 (0:0) | |
| 19:00 | Deportivo Maipú | - | Temperley | 2:1 (2:1) | ||
| 19:00 | Quilmes | - | Flandria | 1:0 (1:0) | ||
| 22:10 | Instituto de Córdoba | - | Deportivo Riestra | 1:1 (1:0) | ||
| 14/08/2022 | 17:00 | Tristan Suárez | - | All Boys | 0:1 (0:0) | |
| 18:45 | Chacarita Juniors | - | San Martín de San Juan | 1:1 (0:1) | ||
| 19:00 | Almagro | - | Deportivo Madryn | 1:1 (0:1) | ||
| 19:00 | Brown de Adrogué | - | Chaco For Ever | 1:2 (1:1) | ||
| 19:00 | Defensores de Belgrano | - | San Telmo | 0:0 (0:0) | ||
| 19:00 | Guillermo Brown | - | Atlanta | 1:0 (1:0) | ||
| 20:00 | Alvarado | - | Estudiantes de Río Cuarto | 0:1 (0:0) | ||
| 20:30 | Mitre de SdE | - | Villa Dálmine | 3:2 (0:2) | ||
| 21:40 | San Martín de Tucumán | - | Gimnasia de Mendoza | 0:0 (0:0) | ||
| 15/08/2022 | 19:30 | Nueva Chicago | - | Deportivo Morón | 1:1 (1:0) | |
| 20:00 | Independiente Rivadavia | - | Gimnasia de Jujuy | 3:1 (1:0) | ||
| 16/08/2022 | 01:10 | Ferro Carril Oeste | - | Almirante Brown | 1:0 (1:0) | |
| 17/08/2022 | 01:10 | Agropecuario Argentino | - | Güemes de SdE | 2:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 28 | 17 | 7 | 4 | 32:19 | 13 | 58 |
| 2 |
|
Instituto de Córdoba | 28 | 14 | 10 | 4 | 35:20 | 15 | 52 |
| 3 |
|
San Martín de Tucumán | 28 | 13 | 12 | 3 | 32:16 | 16 | 51 |
| 4 |
|
All Boys | 28 | 12 | 13 | 3 | 38:22 | 16 | 49 |
| 5 |
|
Gimnasia de Mendoza | 28 | 12 | 12 | 4 | 31:12 | 19 | 48 |
| 6 |
|
Estudiantes de Río Cuarto | 28 | 11 | 12 | 5 | 32:26 | 6 | 45 |
| 7 |
|
Chaco For Ever | 29 | 10 | 14 | 5 | 30:21 | 9 | 44 |
| 8 |
|
Estudiantes de Caseros | 29 | 12 | 8 | 9 | 27:25 | 2 | 44 |
| 9 |
|
Almagro | 29 | 12 | 8 | 9 | 28:27 | 1 | 44 |
| 10 |
|
Independiente Rivadavia | 28 | 11 | 9 | 8 | 36:27 | 9 | 42 |
| 11 |
|
Defensores de Belgrano | 28 | 10 | 12 | 6 | 30:22 | 8 | 42 |
| 12 |
|
San Martín de San Juan | 29 | 12 | 6 | 11 | 39:33 | 6 | 42 |
| 13 |
|
Deportivo Maipú | 29 | 9 | 14 | 6 | 35:26 | 9 | 41 |
| 14 |
|
Deportivo Riestra | 28 | 9 | 14 | 5 | 27:22 | 5 | 41 |
| 15 |
|
Deportivo Madryn | 28 | 8 | 14 | 6 | 36:29 | 7 | 38 |
| 16 |
|
Brown de Adrogué | 28 | 10 | 8 | 10 | 33:30 | 3 | 38 |
| 17 |
|
Guillermo Brown | 28 | 11 | 5 | 12 | 25:30 | -5 | 38 |
| 18 |
|
Chacarita Juniors | 28 | 9 | 10 | 9 | 39:35 | 4 | 37 |
| 19 |
|
Deportivo Morón | 28 | 7 | 15 | 6 | 22:17 | 5 | 36 |
| 20 |
|
Mitre de SdE | 28 | 9 | 9 | 10 | 32:32 | 0 | 36 |
| 21 |
|
Ferro Carril Oeste | 28 | 9 | 9 | 10 | 23:27 | -4 | 36 |
| 22 |
|
Agropecuario Argentino | 28 | 7 | 14 | 7 | 24:23 | 1 | 35 |
| 23 |
|
Gimnasia de Jujuy | 28 | 9 | 8 | 11 | 31:38 | -7 | 35 |
| 24 |
|
Güemes de SdE | 28 | 8 | 10 | 10 | 23:23 | 0 | 34 |
| 25 |
|
Quilmes | 28 | 8 | 10 | 10 | 32:35 | -3 | 34 |
| 26 |
|
Almirante Brown | 28 | 7 | 12 | 9 | 30:34 | -4 | 33 |
| 27 |
|
San Telmo | 28 | 7 | 10 | 11 | 26:39 | -13 | 31 |
| 28 |
|
Atlanta | 29 | 6 | 12 | 11 | 22:28 | -6 | 30 |
| 29 |
|
Temperley | 28 | 5 | 13 | 10 | 24:33 | -9 | 28 |
| 30 |
|
Alvarado | 29 | 6 | 10 | 13 | 26:43 | -17 | 28 |
| 31 |
|
Nueva Chicago | 29 | 5 | 12 | 12 | 29:41 | -12 | 27 |
| 32 |
|
Villa Dálmine | 28 | 5 | 12 | 11 | 32:46 | -14 | 27 |
| 33 |
|
Atlético Rafaela | 28 | 5 | 11 | 12 | 29:36 | -7 | 26 |
| 34 |
|
Flandria | 28 | 5 | 10 | 13 | 27:38 | -11 | 25 |
| 35 |
|
Tristan Suárez | 28 | 5 | 9 | 14 | 27:34 | -7 | 24 |
| 36 |
|
Sacachispas | 28 | 3 | 15 | 10 | 19:32 | -13 | 24 |
| 37 |
|
Ramón Santamarina | 28 | 5 | 9 | 14 | 21:43 | -22 | 24 |
| Promotion | |
| Playoffs | |
| Playoffs | |
| Relegation |
