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| 02/09/2022 | 00:00 | Huracán | - | Central Córdoba SdE | 2:0 (0:0) | |
| 03/09/2022 | 16:00 | Lanús | - | Tigre | 1:2 (0:1) | |
| 17:00 | Rosario Central | - | Talleres de Córdoba | 1:0 (1:0) | ||
| 19:30 | Aldosivi | - | Sarmiento de Junín | 1:2 (0:1) | ||
| 19:30 | Vélez Sarsfield | - | Newell's Old Boys | 0:1 (0:0) | ||
| 22:00 | Racing Club | - | Argentinos Juniors | 1:0 (0:0) | ||
| 04/09/2022 | 00:30 | Gimnasia de La Plata | - | Independiente | 3:1 (1:1) | |
| 19:30 | Patronato de Paraná | - | Unión de Santa Fe | 0:0 (0:0) | ||
| 19:30 | Platense | - | Estudiantes | 0:0 (0:0) | ||
| 22:00 | Colón de Santa Fe | - | Boca Juniors | 1:2 (1:1) | ||
| 05/09/2022 | 00:30 | River Plate | - | Barracas Central | 2:0 (1:0) | |
| 23:00 | Godoy Cruz | - | Arsenal de Sarandí | 1:0 (1:0) | ||
| 23:00 | Defensa y Justicia | - | San Lorenzo | 0:0 (0:0) | ||
| 06/09/2022 | 01:30 | Atlético Tucumán | - | Banfield | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Tucumán | 17 | 9 | 6 | 2 | 19:8 | 11 | 33 |
|
Gimnasia de La Plata | 17 | 9 | 6 | 2 | 19:8 | 11 | 33 | |
| 3 |
|
Huracán | 17 | 8 | 7 | 2 | 21:12 | 9 | 31 |
| 4 |
|
Godoy Cruz | 17 | 9 | 4 | 4 | 21:14 | 7 | 31 |
| 5 |
|
River Plate | 17 | 8 | 5 | 4 | 27:14 | 13 | 29 |
| 6 |
|
Boca Juniors | 17 | 9 | 2 | 6 | 23:22 | 1 | 29 |
| 7 |
|
Racing Club | 17 | 7 | 7 | 3 | 24:14 | 10 | 28 |
| 8 |
|
Argentinos Juniors | 17 | 8 | 3 | 6 | 18:15 | 3 | 27 |
| 9 |
|
Platense | 17 | 6 | 8 | 3 | 17:13 | 4 | 26 |
| 10 |
|
San Lorenzo | 17 | 5 | 10 | 2 | 22:17 | 5 | 25 |
| 11 |
|
Patronato de Paraná | 17 | 6 | 6 | 5 | 22:19 | 3 | 24 |
| 12 |
|
Unión de Santa Fe | 17 | 6 | 6 | 5 | 22:24 | -2 | 24 |
| 13 |
|
Estudiantes | 17 | 6 | 5 | 6 | 16:17 | -1 | 23 |
| 14 |
|
Newell's Old Boys | 17 | 6 | 5 | 6 | 15:16 | -1 | 23 |
| 15 |
|
Tigre | 17 | 5 | 7 | 5 | 24:22 | 2 | 22 |
| 16 |
|
Sarmiento de Junín | 17 | 6 | 4 | 7 | 18:21 | -3 | 22 |
| 17 |
|
Rosario Central | 17 | 6 | 4 | 7 | 13:16 | -3 | 22 |
| 18 |
|
Barracas Central | 17 | 5 | 5 | 7 | 18:26 | -8 | 20 |
| 19 |
|
Arsenal de Sarandí | 17 | 3 | 10 | 4 | 16:18 | -2 | 19 |
| 20 |
|
Banfield | 17 | 4 | 7 | 6 | 15:17 | -2 | 19 |
| 21 |
|
Defensa y Justicia | 17 | 4 | 7 | 6 | 14:18 | -4 | 19 |
| 22 |
|
Central Córdoba SdE | 17 | 5 | 3 | 9 | 19:25 | -6 | 18 |
| 23 |
|
Colón de Santa Fe | 17 | 4 | 6 | 7 | 14:20 | -6 | 18 |
| 24 |
|
Talleres de Córdoba | 17 | 3 | 7 | 7 | 14:18 | -4 | 16 |
| 25 |
|
Independiente | 17 | 3 | 6 | 8 | 16:22 | -6 | 15 |
| 26 |
|
Aldosivi | 17 | 3 | 4 | 10 | 11:25 | -14 | 13 |
| 27 |
|
Vélez Sarsfield | 17 | 1 | 9 | 7 | 17:23 | -6 | 12 |
| 28 |
|
Lanús | 17 | 2 | 5 | 10 | 15:26 | -11 | 11 |
