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| 13/07/2022 | 14:00 | San Lorenzo II | - | Banfield II | 0:1 (0:1) | |
| 15:00 | Talleres de Córdoba II | - | Boca Juniors II | 1:2 (1:1) | ||
| 15:00 | Defensa y Justicia II | - | Sarmiento de Junín II | 3:1 (2:0) | ||
| 15:00 | Patronato de Paraná II | - | Central Córdoba SdE II | 0:1 (0:0) | ||
| 14/07/2022 | 14:00 | Argentinos Juniors II | - | Barracas Central II | 2:0 (0:0) | |
| 14:00 | Racing Club II | - | Newell's Old Boys II | 4:4 (2:2) | ||
| 15:00 | Atlético Tucumán II | - | Aldosivi II | 6:2 (3:1) | ||
| 15:00 | Rosario Central II | - | Independiente II | 5:1 (2:1) | ||
| 15/07/2022 | 14:00 | Estudiantes II | - | Tigre II | 0:2 (0:1) | |
| 15:00 | Platense II | - | Arsenal de Sarandí II | 1:1 (0:0) | ||
| 15:00 | Lanús II | - | Godoy Cruz II | 2:3 (0:3) | ||
| 15:00 | Huracán II | - | Unión de Santa Fe II | 4:2 (1:1) | ||
| 16/07/2022 | 14:00 | Colón de Santa Fe II | - | Gimnasia de La Plata II | 0:2 (0:1) | |
| 14:00 | River Plate II | - | Vélez Sarsfield II | 0:2 (0:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Vélez Sarsfield II | 8 | 5 | 1 | 2 | 14:6 | 8 | 16 |
| 2 |
|
Tigre II | 8 | 5 | 1 | 2 | 10:8 | 2 | 16 |
| 3 |
|
Rosario Central II | 8 | 4 | 3 | 1 | 19:11 | 8 | 15 |
| 4 |
|
Argentinos Juniors II | 8 | 4 | 3 | 1 | 12:4 | 8 | 15 |
| 5 |
|
River Plate II | 8 | 5 | 0 | 3 | 11:6 | 5 | 15 |
| 6 |
|
Defensa y Justicia II | 8 | 5 | 0 | 3 | 9:9 | 0 | 15 |
| 7 |
|
Racing Club II | 8 | 4 | 2 | 2 | 21:10 | 11 | 14 |
| 8 |
|
Gimnasia de La Plata II | 8 | 4 | 2 | 2 | 12:7 | 5 | 14 |
| 9 |
|
Atlético Tucumán II | 8 | 4 | 2 | 2 | 15:11 | 4 | 14 |
| 10 |
|
Central Córdoba SdE II | 8 | 4 | 2 | 2 | 10:8 | 2 | 14 |
| 11 |
|
Independiente II | 8 | 4 | 1 | 3 | 15:11 | 4 | 13 |
| 12 |
|
Newell's Old Boys II | 8 | 3 | 4 | 1 | 11:7 | 4 | 13 |
| 13 |
|
Arsenal de Sarandí II | 8 | 3 | 3 | 2 | 7:5 | 2 | 12 |
| 14 |
|
Boca Juniors II | 8 | 4 | 0 | 4 | 10:9 | 1 | 12 |
| 15 |
|
Godoy Cruz II | 8 | 3 | 2 | 3 | 10:8 | 2 | 11 |
| 16 |
|
Huracán II | 8 | 3 | 2 | 3 | 12:14 | -2 | 11 |
| 17 |
|
Unión de Santa Fe II | 8 | 3 | 1 | 4 | 9:10 | -1 | 10 |
| 18 |
|
San Lorenzo II | 8 | 3 | 1 | 4 | 8:9 | -1 | 10 |
| 19 |
|
Banfield II | 8 | 3 | 1 | 4 | 6:8 | -2 | 10 |
| 20 |
|
Colón de Santa Fe II | 8 | 2 | 4 | 2 | 8:11 | -3 | 10 |
| 21 |
|
Aldosivi II | 8 | 3 | 1 | 4 | 15:20 | -5 | 10 |
| 22 |
|
Barracas Central II | 8 | 3 | 0 | 5 | 5:12 | -7 | 9 |
| 23 |
|
Talleres de Córdoba II | 8 | 2 | 2 | 4 | 10:12 | -2 | 8 |
| 24 |
|
Lanús II | 8 | 2 | 1 | 5 | 10:16 | -6 | 7 |
| 25 |
|
Estudiantes II | 8 | 1 | 3 | 4 | 4:9 | -5 | 6 |
| 26 |
|
Sarmiento de Junín II | 8 | 1 | 2 | 5 | 6:16 | -10 | 5 |
| 27 |
|
Patronato de Paraná II | 8 | 1 | 1 | 6 | 5:19 | -14 | 4 |
| 28 |
|
Platense II | 8 | 0 | 3 | 5 | 4:12 | -8 | 3 |
