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| 1st(1st leg) | Camioneros | - | Deportivo Maipú | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo Maipú | - | Camioneros | 4:2 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 31/03/2019 20:00 | 2nd (2nd leg): 07/04/2019 20:45 | Winner: Deportivo Maipú | ||||
| 1st(1st leg) | Sol de Mayo de Viedma | - | Unión de Sunchales | 3:0 (2:0) | ||
| 2nd (2nd leg) | Unión de Sunchales | - | Sol de Mayo de Viedma | 1:1 (1:0) | ||
| 1st(1st leg): 31/03/2019 20:00 | 2nd (2nd leg): 07/04/2019 20:00 | Winner: Sol de Mayo de Viedma | ||||
| 1st(1st leg) | Boca Unidos | - | Desamparados de San Juan | 0:0 (0:0) | ||
| 2nd (2nd leg) | Desamparados de San Juan | - | Boca Unidos | 4:3 (0:1, 1:1, 1:1) pso | ||
| 1st(1st leg): 31/03/2019 23:00 | 2nd (2nd leg): 07/04/2019 20:00 | Winner: Desamparados de San Juan | ||||
| 1st(1st leg) | Deportivo Madryn | - | Villa Mitre de Bahía Blanca | 2:0 (1:0) | ||
| 2nd (2nd leg) | Villa Mitre de Bahía Blanca | - | Deportivo Madryn | 1:1 (0:0) | ||
| 1st(1st leg): 16/04/2019 20:00 | 2nd (2nd leg): 22/04/2019 00:00 | Winner: Deportivo Madryn | ||||
| 1st(1st leg) | San Martín de Formosa | - | Huracán de Las Heras | 1:1 (1:0) | ||
| 2nd (2nd leg) | Huracán de Las Heras | - | San Martín de Formosa | 1:0 (0:0) | ||
| 1st(1st leg): 16/04/2019 21:00 | 2nd (2nd leg): 21/04/2019 20:00 | Winner: Huracán de Las Heras | ||||
| 1st(1st leg) | Sportivo Las Parejas | - | Sansinena de Gral. Cerri | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sansinena de Gral. Cerri | - | Sportivo Las Parejas | 2:3 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 17/04/2019 00:00 | 2nd (2nd leg): 21/04/2019 20:00 | Winner: Sportivo Las Parejas | ||||
| 1st(1st leg) | Estudiantes de San Luis | - | Chaco For Ever | 0:0 (0:0) | ||
| 2nd (2nd leg) | Chaco For Ever | - | Estudiantes de San Luis | 1:0 (0:0) | ||
| 1st(1st leg): 17/04/2019 01:30 | 2nd (2nd leg): 21/04/2019 20:30 | Winner: Chaco For Ever | ||||
