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| 02/10/2022 | 01:00 | Sarmiento de Resistencia | - | Central Norte | 1:1 (0:0) | |
| 15:00 | Juventud Unida de Gualeguaychú | - | Gimnasia y Tiro de Salta | 2:2 (0:0) | ||
| 20:00 | Boca Unidos | - | Atlético Paraná | 0:0 (0:0) | ||
| 20:00 | Douglas Haig | - | Defensores Belgrano (VR) | 1:0 (0:0) | ||
| 20:00 | Gimnasia y Esgrima (CdU) | - | Unión de Sunchales | 1:0 (0:0) | ||
| 20:30 | Racing de Córdoba | - | Defensores de Pronunciamiento | 1:0 (1:0) | ||
| 23:00 | Juventud Antoniana | - | Sportivo Las Parejas | 5:0 (2:0) | ||
| 04/10/2022 | 00:30 | Belgrano de San Francisco | - | San Martín de Formosa | 2:1 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 30 | 19 | 9 | 2 | 50:14 | 36 | 66 |
| 2 |
|
Sarmiento de Resistencia | 30 | 18 | 9 | 3 | 42:16 | 26 | 63 |
| 3 |
|
San Martín de Formosa | 30 | 16 | 7 | 7 | 54:29 | 25 | 55 |
| 4 |
|
Central Norte | 30 | 15 | 10 | 5 | 43:24 | 19 | 55 |
| 5 |
|
Gimnasia y Tiro de Salta | 30 | 14 | 8 | 8 | 31:29 | 2 | 50 |
| 6 |
|
Douglas Haig | 30 | 13 | 7 | 10 | 40:30 | 10 | 46 |
| 7 |
|
Belgrano de San Francisco | 30 | 12 | 6 | 12 | 38:34 | 4 | 42 |
| 8 |
|
Sportivo Las Parejas | 30 | 11 | 9 | 10 | 32:33 | -1 | 42 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 30 | 12 | 5 | 13 | 29:35 | -6 | 41 |
| 10 |
|
Juventud Antoniana | 31 | 11 | 7 | 13 | 34:39 | -5 | 40 |
| 11 |
|
Crucero del Norte | 30 | 10 | 7 | 13 | 24:40 | -16 | 37 |
| 12 |
|
Boca Unidos | 30 | 7 | 12 | 11 | 29:34 | -5 | 33 |
| 13 |
|
Defensores de Pronunciamiento | 30 | 7 | 9 | 14 | 25:36 | -11 | 30 |
| 14 |
|
Defensores Belgrano (VR) | 31 | 8 | 5 | 18 | 24:37 | -13 | 29 |
| 15 |
|
Unión de Sunchales | 30 | 8 | 5 | 17 | 29:46 | -17 | 29 |
| 16 |
|
Atlético Paraná | 30 | 5 | 8 | 17 | 22:44 | -22 | 23 |
| 17 |
|
Juventud Unida de Gualeguaychú | 30 | 6 | 5 | 19 | 27:53 | -26 | 23 |
| Playoffs |
