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| 21/04/2006 | 19:30 | RSC Anderlecht | - | Standard Liège | 2:0 (1:0) | |
| 22/04/2006 | 19:00 | KSV Roeselare | - | FC Brussels | 0:1 (0:1) | |
| 19:00 | Sporting Charleroi | - | SV Zulte Waregem | 2:0 (1:0) | ||
| 19:00 | KSK Beveren | - | Germinal Beerschot | 0:0 (0:0) | ||
| 19:00 | Sint-Truidense VV | - | KRC Genk | 2:2 (1:1) | ||
| 19:00 | Lierse SK | - | Excelsior Mouscron | 2:0 (2:0) | ||
| 19:00 | Sporting Lokeren | - | RAA La Louviére | 3:2 (2:2) | ||
| 23/04/2006 | 17:00 | KVC Westerlo | - | KAA Gent | 0:1 (0:1) | |
| 19:30 | Club Brugge KV | - | Cercle Brugge | 2:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RSC Anderlecht | 32 | 19 | 9 | 4 | 69:27 | 42 | 66 |
| 2 |
|
Standard Liège | 32 | 19 | 7 | 6 | 51:26 | 25 | 64 |
| 3 |
|
Club Brugge KV | 32 | 17 | 9 | 6 | 47:32 | 15 | 60 |
| 4 |
|
KAA Gent | 32 | 17 | 6 | 9 | 46:34 | 12 | 57 |
| 5 |
|
KRC Genk | 32 | 15 | 9 | 8 | 50:35 | 15 | 54 |
| 6 |
|
SV Zulte Waregem | 32 | 14 | 7 | 11 | 50:44 | 6 | 49 |
| 7 |
|
Sporting Lokeren | 32 | 12 | 11 | 9 | 47:45 | 2 | 47 |
| 8 |
|
Germinal Beerschot | 32 | 13 | 6 | 13 | 47:43 | 4 | 45 |
| 9 |
|
Sporting Charleroi | 32 | 11 | 11 | 10 | 37:36 | 1 | 44 |
| 10 |
|
KSV Roeselare | 32 | 10 | 10 | 12 | 44:41 | 3 | 40 |
| 11 |
|
FC Brussels | 32 | 10 | 10 | 12 | 27:29 | -2 | 40 |
| 12 |
|
KVC Westerlo | 32 | 11 | 7 | 14 | 38:46 | -8 | 40 |
| 13 |
|
Excelsior Mouscron | 32 | 10 | 4 | 18 | 40:42 | -2 | 34 |
| 14 |
|
Sint-Truidense VV | 32 | 8 | 10 | 14 | 36:45 | -9 | 34 |
| 15 |
|
Cercle Brugge | 32 | 8 | 7 | 17 | 35:61 | -26 | 31 |
| 16 |
|
KSK Beveren | 32 | 8 | 6 | 18 | 34:53 | -19 | 30 |
| 17 |
|
Lierse SK | 32 | 7 | 8 | 17 | 20:50 | -30 | 29 |
| 18 |
|
RAA La Louviére | 32 | 4 | 13 | 15 | 23:52 | -29 | 25 |
