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| 1st(1st leg) | Proleter Teslić | - | Zrinjski Mostar | 4:2 (2:0) | ||
| 2nd (2nd leg) | Zrinjski Mostar | - | Proleter Teslić | 3:0 (0:0) | ||
| 1st(1st leg): 28/09/2010 14:30 | 2nd (2nd leg): 19/10/2010 13:30 | Winner: Zrinjski Mostar | ||||
| 1st(1st leg) | Leotar Trebinje | - | HNK Branitelj | 1:1 (1:1) | ||
| 2nd (2nd leg) | HNK Branitelj | - | Leotar Trebinje | 1:0 (1:0) | ||
| 1st(1st leg): 29/09/2010 14:30 | 2nd (2nd leg): 20/10/2010 13:30 | Winner: HNK Branitelj | ||||
| 1st(1st leg) | FK Sarajevo | - | Sloboda Novi Grad | 4:1 (2:1) | ||
| 2nd (2nd leg) | Sloboda Novi Grad | - | FK Sarajevo | 1:3 (1:2) | ||
| 1st(1st leg): 29/09/2010 14:30 | 2nd (2nd leg): 20/10/2010 13:30 | Winner: FK Sarajevo | ||||
| 1st(1st leg) | Čelik Zenica | - | Slavija Sarajevo | 1:1 (1:0) | ||
| 2nd (2nd leg) | Slavija Sarajevo | - | Čelik Zenica | 0:1 (0:1) | ||
| 1st(1st leg): 29/09/2010 14:30 | 2nd (2nd leg): 20/10/2010 13:30 | Winner: Čelik Zenica | ||||
| 1st(1st leg) | FK Kozara | - | Sloboda Tuzla | 1:1 (1:1) | ||
| 2nd (2nd leg) | Sloboda Tuzla | - | FK Kozara | 4:2 (2:1) | ||
| 1st(1st leg): 29/09/2010 14:30 | 2nd (2nd leg): 20/10/2010 13:30 | Winner: Sloboda Tuzla | ||||
| 1st(1st leg) | Omladinac Mionica | - | Široki Brijeg | 2:0 (1:0) | ||
| 2nd (2nd leg) | Široki Brijeg | - | Omladinac Mionica | 4:0 (2:0) | ||
| 1st(1st leg): 29/09/2010 14:30 | 2nd (2nd leg): 20/10/2010 13:30 | Winner: Široki Brijeg | ||||
| 1st(1st leg) | Borac Banja Luka | - | Željezničar Sarajevo | 0:0 (0:0) | ||
| 2nd (2nd leg) | Željezničar Sarajevo | - | Borac Banja Luka | 3:0 (1:0) | ||
| 1st(1st leg): 29/09/2010 16:00 | 2nd (2nd leg): 20/10/2010 16:00 | Winner: Željezničar Sarajevo | ||||
| 1st(1st leg) | Olimpic Sarajevo | - | UNIS Vogošća | 3:1 (1:0) | ||
| 2nd (2nd leg) | UNIS Vogošća | - | Olimpic Sarajevo | 1:2 (1:1) | ||
| 1st(1st leg): 30/09/2010 14:30 | 2nd (2nd leg): 19/10/2010 13:30 | Winner: Olimpic Sarajevo | ||||
