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| 1st(1st leg) | Mariscal Sucre | - | Vaca Díez | 2:1 | ||
| 2nd (2nd leg) | Vaca Díez | - | Mariscal Sucre | 3:0 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 28/11/2020 | Winner: Vaca Díez | ||||
| 1st(1st leg) | Municipal de Tiquipaya | - | Deportivo FATIC | 2:3 | ||
| 2nd (2nd leg) | Deportivo FATIC | - | Municipal de Tiquipaya | 2:1 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 28/11/2020 19:30 | Winner: Deportivo FATIC | ||||
| 1st(1st leg) | Chaco Petrolero | - | Cochabamba FC | 2:0 | ||
| 2nd (2nd leg) | Cochabamba FC | - | Chaco Petrolero | 3:0 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 28/11/2020 19:30 | Winner: Cochabamba FC | ||||
| 1st(1st leg) | Rosario Central de Potosí | - | Oruro Royal | 1:1 | ||
| 2nd (2nd leg) | Oruro Royal | - | Rosario Central de Potosí | 0:0 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 28/11/2020 19:30 | Winner: Oruro Royal | ||||
| 1st(1st leg) | Empresa Minera Huanuni | - | Stormers de Potosí | 3:1 | ||
| 2nd (2nd leg) | Stormers de Potosí | - | Empresa Minera Huanuni | 6:2 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 28/11/2020 19:00 | Winner: Stormers de Potosí | ||||
| 1st(1st leg) | Satélite Norte | - | Libertad Gran Mamoré | 1:1 | ||
| 2nd (2nd leg) | Libertad Gran Mamoré | - | Satélite Norte | 4:1 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 29/11/2020 20:00 | Winner: Libertad Gran Mamoré | ||||
| 1st(1st leg) | Quebracho | - | Independiente Petrolero | 3:2 | ||
| 2nd (2nd leg) | Independiente Petrolero | - | Quebracho | 5:4 pso | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 29/11/2020 19:30 | Winner: Independiente Petrolero | ||||
| 1st(1st leg) | Fancesa | - | Real Tomayapo | 3:1 | ||
| 2nd (2nd leg) | Real Tomayapo | - | Fancesa | 3:1 | ||
| 1st(1st leg): 25/11/2020 19:30 | 2nd (2nd leg): 28/11/2020 23:30 | |||||
| 1st(1st leg) | Deportivo Kivón | - | Torre Fuerte | 2:7 | ||
| 2nd (2nd leg) | Torre Fuerte | - | Deportivo Kivón | 1:1 | ||
| 1st(1st leg): 26/11/2020 00:00 | 2nd (2nd leg): 28/11/2020 19:30 | Winner: Torre Fuerte | ||||
