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| 1st(1st leg) | Empresa Minera Huanuni | - | Real Tomayapo | 2:1 | ||
| 2nd (2nd leg) | Real Tomayapo | - | Empresa Minera Huanuni | 5:0 | ||
| 1st(1st leg): 02/12/2020 19:30 | 2nd (2nd leg): 05/12/2020 19:30 | Winner: Real Tomayapo | ||||
| 1st(1st leg) | Chaco Petrolero | - | Independiente Petrolero | 0:2 | ||
| 2nd (2nd leg) | Independiente Petrolero | - | Chaco Petrolero | 5:0 | ||
| 1st(1st leg): 02/12/2020 19:30 | 2nd (2nd leg): 05/12/2020 19:30 | Winner: Independiente Petrolero | ||||
| 1st(1st leg) | Fancesa | - | Deportivo FATIC | 2:1 | ||
| 2nd (2nd leg) | Deportivo FATIC | - | Fancesa | 1:2 | ||
| 1st(1st leg): 02/12/2020 19:30 | 2nd (2nd leg): 05/12/2020 19:30 | Winner: Fancesa | ||||
| 1st(1st leg) | Torre Fuerte | - | Libertad Gran Mamoré | 1:3 | ||
| 2nd (2nd leg) | Libertad Gran Mamoré | - | Torre Fuerte | 0:1 | ||
| 1st(1st leg): 02/12/2020 19:30 | 2nd (2nd leg): 05/12/2020 19:30 | Winner: Libertad Gran Mamoré | ||||
| 1st(1st leg) | Cochabamba FC | - | Stormers de Potosí | 1:1 | ||
| 2nd (2nd leg) | Stormers de Potosí | - | Cochabamba FC | 1:1 | ||
| 1st(1st leg): 02/12/2020 19:30 | 2nd (2nd leg): 05/12/2020 19:30 | |||||
| 1st(1st leg) | Oruro Royal | - | Vaca Díez | 2:3 | ||
| 2nd (2nd leg) | Vaca Díez | - | Oruro Royal | 2:2 | ||
| 1st(1st leg): 02/12/2020 20:00 | 2nd (2nd leg): 05/12/2020 19:30 | Winner: Vaca Díez | ||||
