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| 1st(1st leg) | Empresa Minera Huanuni | - | Vaca Díez | 2:1 | ||
| 2nd (2nd leg) | Vaca Díez | - | Empresa Minera Huanuni | 4:2 pso | ||
| 1st(1st leg): 06/11/2021 19:00 | 2nd (2nd leg): 14/11/2021 19:00 | Winner: Vaca Díez | ||||
| 1st(1st leg) | Torre Fuerte | - | Universitario de Sucre | 2:3 | ||
| 2nd (2nd leg) | Universitario de Sucre | - | Torre Fuerte | 3:0 | ||
| 1st(1st leg): 07/11/2021 17:00 | 2nd (2nd leg): 14/11/2021 21:00 | Winner: Universitario de Sucre | ||||
| 1st(1st leg) | San Antonio Bulo Bulo | - | García Agreda | 2:2 | ||
| 2nd (2nd leg) | García Agreda | - | San Antonio Bulo Bulo | 5:2 | ||
| 1st(1st leg): 07/11/2021 19:00 | 2nd (2nd leg): 13/11/2021 19:00 | Winner: García Agreda | ||||
| 1st(1st leg) | Ciudad Nueva Santa Cruz | - | Universitario de Vinto | 0:1 | ||
| 2nd (2nd leg) | Universitario de Vinto | - | Ciudad Nueva Santa Cruz | 3:2 | ||
| 1st(1st leg): 08/11/2021 19:00 | 2nd (2nd leg): 14/11/2021 19:00 | Winner: Universitario de Vinto | ||||
