1st(1st leg) Hercílio Luz - SC - Chapecoense annull.
2nd (2nd leg) Chapecoense - Hercílio Luz - SC annull.
1st(1st leg): 25/04/2021 20:00 2nd (2nd leg): 29/04/2021 01:30
1st(1st leg) Joinville - SC - Brusque - SC 2:2 (2:1)
2nd (2nd leg) Brusque - SC - Joinville - SC 1:0 (0:0)
1st(1st leg): 25/04/2021 20:00 2nd (2nd leg): 28/04/2021 23:00 Winner: Brusque - SC
1st(1st leg) Marcílio Dias - SC - Juventus - SC 1:0 (1:0)
2nd (2nd leg) Juventus - SC - Marcílio Dias - SC 0:1 (0:0)
1st(1st leg): 25/04/2021 23:00 2nd (2nd leg): 28/04/2021 23:00 Winner: Marcílio Dias - SC
1st(1st leg) Próspera - SC - Avaí - SC 0:1 (0:0)
2nd (2nd leg) Avaí - SC - Próspera - SC 2:1 (1:0)
1st(1st leg): 25/04/2021 23:00 2nd (2nd leg): 29/04/2021 00:30 Winner: Avaí - SC
1st(1st leg) Figueirense - SC - Chapecoense 3:1 (3:0)
2nd (2nd leg) Chapecoense - Figueirense - SC 2:0 (1:0)
1st(1st leg): 09/05/2021 20:00 2nd (2nd leg): 13/05/2021 00:30 Winner: Chapecoense