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| 1st(1st leg) | Figueirense - SC | - | Hercílio Luz - SC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Hercílio Luz - SC | - | Figueirense - SC | 0:0 (0:0) | ||
| 1st(1st leg): 12/03/2022 19:30 | 2nd (2nd leg): 20/03/2022 14:00 | Winner: Figueirense - SC | ||||
| 1st(1st leg) | Marcílio Dias - SC | - | Camboriú - SC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Camboriú - SC | - | Marcílio Dias - SC | 3:2 (2:0) | ||
| 1st(1st leg): 12/03/2022 22:00 | 2nd (2nd leg): 19/03/2022 22:00 | Winner: Camboriú - SC | ||||
| 1st(1st leg) | Chapecoense | - | Concórdia - SC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Concórdia - SC | - | Chapecoense | 1:1 (0:0) | ||
| 1st(1st leg): 13/03/2022 19:00 | 2nd (2nd leg): 20/03/2022 19:00 | |||||
| 1st(1st leg) | Avaí - SC | - | Brusque - SC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Brusque - SC | - | Avaí - SC | 0:0 (0:0) | ||
| 1st(1st leg): 13/03/2022 21:30 | 2nd (2nd leg): 19/03/2022 19:30 | Winner: Brusque - SC | ||||
