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| 1st(1st leg) | Athletico Paranaense | - | Santos FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Santos FC | - | Athletico Paranaense | 0:1 (0:0) | ||
| 1st(1st leg): 25/08/2021 23:00 | 2nd (2nd leg): 15/09/2021 01:30 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | São Paulo FC | - | Fortaleza | 2:2 (0:0) | ||
| 2nd (2nd leg) | Fortaleza | - | São Paulo FC | 3:1 (1:0) | ||
| 1st(1st leg): 26/08/2021 01:30 | 2nd (2nd leg): 16/09/2021 01:30 | Winner: Fortaleza | ||||
| 1st(1st leg) | Grêmio Porto Alegre | - | Flamengo RJ | 0:4 (0:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Grêmio Porto Alegre | 2:0 (0:0) | ||
| 1st(1st leg): 26/08/2021 01:30 | 2nd (2nd leg): 16/09/2021 01:30 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Fluminense RJ | - | Atlético Mineiro | 1:2 (1:2) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Fluminense RJ | 1:0 (0:0) | ||
| 1st(1st leg): 27/08/2021 01:30 | 2nd (2nd leg): 15/09/2021 23:00 | Winner: Atlético Mineiro | ||||
