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| 1st(1st leg) | Floresta - CE | - | Ferroviário - CE | 0:0 (0:0) | ||
| 2nd (2nd leg) | Ferroviário - CE | - | Floresta - CE | 3:4 (0:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 27/10/2021 01:30 | 2nd (2nd leg): 03/11/2021 00:30 | Winner: Floresta - CE | ||||
| 1st(1st leg) | Botafogo - PB | - | Vitória - BA | 1:1 (0:1) | ||
| 2nd (2nd leg) | Vitória - BA | - | Botafogo - PB | 5:6 (2:0, 2:2) pso | ||
| 1st(1st leg): 27/10/2021 01:30 | 2nd (2nd leg): 19/11/2021 00:30 | Winner: Botafogo - PB | ||||
| 1st(1st leg) | Sousa - PB | - | ABC - RN | 3:0 (2:0) | ||
| 2nd (2nd leg) | ABC - RN | - | Sousa - PB | 2:1 (0:0) | ||
| 1st(1st leg): 27/10/2021 19:30 | 2nd (2nd leg): 09/11/2021 23:30 | Winner: Sousa - PB | ||||
| 1st(1st leg) | Moto Club - MA | - | CR Brasil - AL | 2:1 (1:1) | ||
| 2nd (2nd leg) | CR Brasil - AL | - | Moto Club - MA | 2:0 (1:0) | ||
| 1st(1st leg): 30/10/2021 19:30 | 2nd (2nd leg): 18/11/2021 22:00 | Winner: CR Brasil - AL | ||||
