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| 1st(1st leg) | Vila Nova - GO | - | Nova Mutum - MT | 3:0 (0:0) | ||
| 2nd (2nd leg) | Nova Mutum - MT | - | Vila Nova - GO | 1:1 (0:0) | ||
| 1st(1st leg): 24/11/2021 22:30 | 2nd (2nd leg): 02/12/2021 19:00 | Winner: Vila Nova - GO | ||||
| 1st(1st leg) | Paysandu - PA | - | Remo - PA | 2:2 (2:0) | ||
| 2nd (2nd leg) | Remo - PA | - | Paysandu - PA | 2:0 (1:0) | ||
| 1st(1st leg): 01/12/2021 23:00 | 2nd (2nd leg): 04/12/2021 20:00 | Winner: Remo - PA | ||||
