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| 1st(1st leg) | Paysandu - PA | - | Castanhal - PA | 1:1 (1:0) | ||
| 2nd (2nd leg) | Castanhal - PA | - | Paysandu - PA | 1:3 (1:1) | ||
| 1st(1st leg): 28/10/2021 00:00 | 2nd (2nd leg): 10/11/2021 22:30 | Winner: Paysandu - PA | ||||
| 1st(1st leg) | Brasiliense - DF | - | Nova Mutum - MT | 1:0 (0:0) | ||
| 2nd (2nd leg) | Nova Mutum - MT | - | Brasiliense - DF | 3:2 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 28/10/2021 19:00 | 2nd (2nd leg): 03/11/2021 19:00 | Winner: Nova Mutum - MT | ||||
| 1st(1st leg) | Aquidauanense - MS | - | Vila Nova - GO | 0:1 (0:1) | ||
| 2nd (2nd leg) | Vila Nova - GO | - | Aquidauanense - MS | 7:0 (2:0) | ||
| 1st(1st leg): 28/10/2021 20:00 | 2nd (2nd leg): 04/11/2021 22:30 | Winner: Vila Nova - GO | ||||
| 1st(1st leg) | Manaus - AM | - | Remo - PA | 1:1 (0:0) | ||
| 2nd (2nd leg) | Remo - PA | - | Manaus - AM | 3:0 (2:0) | ||
| 1st(1st leg): 12/11/2021 20:30 | 2nd (2nd leg): 24/11/2021 23:30 | Winner: Remo - PA | ||||
