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| 1st(1st leg) | Floresta - CE | - | Itabaiana - SE | 2:1 (2:0) | ||
| 2nd (2nd leg) | Itabaiana - SE | - | Floresta - CE | 2:2 (0:0) | ||
| 1st(1st leg): 05/12/2020 18:00 | 2nd (2nd leg): 12/12/2020 18:00 | Winner: Floresta - CE | ||||
| 1st(1st leg) | Atlético de Alagoinhas - BA | - | Goiânia - GO | 1:1 (0:0) | ||
| 2nd (2nd leg) | Goiânia - GO | - | Atlético de Alagoinhas - BA | 3:2 (2:1) | ||
| 1st(1st leg): 05/12/2020 18:00 | 2nd (2nd leg): 12/12/2020 19:00 | Winner: Goiânia - GO | ||||
| 1st(1st leg) | Juventude - MA | - | Bragantino - PA | 1:1 (1:1) | ||
| 2nd (2nd leg) | Bragantino - PA | - | Juventude - MA | 3:4 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 05/12/2020 18:30 | 2nd (2nd leg): 12/12/2020 18:00 | Winner: Juventude - MA | ||||
| 1st(1st leg) | Marcílio Dias - SC | - | Ferroviária - SP | 0:0 (0:0) | ||
| 2nd (2nd leg) | Ferroviária - SP | - | Marcílio Dias - SC | 1:2 (1:0) | ||
| 1st(1st leg): 05/12/2020 19:00 | 2nd (2nd leg): 13/12/2020 21:00 | Winner: Marcílio Dias - SC | ||||
| 1st(1st leg) | S.E.R. Caxias - RS | - | Mirassol - SP | 1:0 (1:0) | ||
| 2nd (2nd leg) | Mirassol - SP | - | S.E.R. Caxias - RS | 3:0 (1:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 05/12/2020 19:00 | 2nd (2nd leg): 13/12/2020 18:30 | Winner: Mirassol - SP | ||||
| 1st(1st leg) | Cascavel FC - PR | - | Grêmio Novorizontino - SP | 1:0 (0:0) | ||
| 2nd (2nd leg) | Grêmio Novorizontino - SP | - | Cascavel FC - PR | 3:0 (1:0) | ||
| 1st(1st leg): 05/12/2020 19:00 | 2nd (2nd leg): 12/12/2020 19:00 | Winner: Grêmio Novorizontino - SP | ||||
| 1st(1st leg) | Coruripe - AL | - | América - RN | 1:0 (0:0) | ||
| 2nd (2nd leg) | América - RN | - | Coruripe - AL | 5:0 (1:0) | ||
| 1st(1st leg): 06/12/2020 18:00 | 2nd (2nd leg): 13/12/2020 18:00 | Winner: América - RN | ||||
| 1st(1st leg) | Globo - RN | - | ABC - RN | 2:1 (1:0) | ||
| 2nd (2nd leg) | ABC - RN | - | Globo - RN | 1:1 (1:0) | ||
| 1st(1st leg): 06/12/2020 18:00 | 2nd (2nd leg): 12/12/2020 18:30 | Winner: Globo - RN | ||||
| 1st(1st leg) | Cabofriense - RJ | - | São Luiz - RS | 1:1 (0:1) | ||
| 2nd (2nd leg) | São Luiz - RS | - | Cabofriense - RJ | 2:0 (1:0) | ||
| 1st(1st leg): 06/12/2020 18:00 | 2nd (2nd leg): 13/12/2020 20:00 | Winner: São Luiz - RS | ||||
| 1st(1st leg) | Real Noroeste - ES | - | Brasiliense - DF | 1:1 (0:1) | ||
| 2nd (2nd leg) | Brasiliense - DF | - | Real Noroeste - ES | 3:0 (1:0) | ||
| 1st(1st leg): 06/12/2020 18:00 | 2nd (2nd leg): 12/12/2020 19:00 | Winner: Brasiliense - DF | ||||
| 1st(1st leg) | Moto Club - MA | - | Fast Clube - AM | 2:2 (0:0) | ||
| 2nd (2nd leg) | Fast Clube - AM | - | Moto Club - MA | 6:5 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 06/12/2020 18:30 | 2nd (2nd leg): 13/12/2020 21:00 | Winner: Fast Clube - AM | ||||
| 1st(1st leg) | Vitória da Conquista - BA | - | Salgueiro - PE | 4:3 (2:0) | ||
| 2nd (2nd leg) | Salgueiro - PE | - | Vitória da Conquista - BA | 4:0 (1:0) | ||
| 1st(1st leg): 06/12/2020 19:00 | 2nd (2nd leg): 13/12/2020 22:00 | Winner: Salgueiro - PE | ||||
| 1st(1st leg) | Tupynambás - MG | - | Aparecidense - GO | 1:1 (0:0) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | Tupynambás - MG | 4:0 (2:0) | ||
| 1st(1st leg): 06/12/2020 19:00 | 2nd (2nd leg): 13/12/2020 19:00 | Winner: Aparecidense - GO | ||||
| 1st(1st leg) | Goianésia - GO | - | Gama - DF | 2:2 (1:1) | ||
| 2nd (2nd leg) | Gama - DF | - | Goianésia - GO | 1:2 (1:2) | ||
| 1st(1st leg): 06/12/2020 19:00 | 2nd (2nd leg): 13/12/2020 19:00 | Winner: Goianésia - GO | ||||
| 1st(1st leg) | Galvez - AC | - | River - PI | 0:0 (0:0) | ||
| 2nd (2nd leg) | River - PI | - | Galvez - AC | 0:1 (0:0) | ||
| 1st(1st leg): 06/12/2020 21:00 | 2nd (2nd leg): 13/12/2020 19:00 | Winner: Galvez - AC | ||||
| 1st(1st leg) | Rio Branco - AC | - | Altos - PI | 0:2 (0:2) | ||
| 2nd (2nd leg) | Altos - PI | - | Rio Branco - AC | 3:1 (1:1) | ||
| 1st(1st leg): 07/12/2020 21:00 | 2nd (2nd leg): 13/12/2020 18:45 | Winner: Altos - PI | ||||
