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| 1st(1st leg) | Atlético Cearense - CE | - | Paragominas - PA | 2:0 (0:0) | ||
| 2nd (2nd leg) | Paragominas - PA | - | Atlético Cearense - CE | 2:1 (2:0) | ||
| 1st(1st leg): 25/09/2021 19:00 | 2nd (2nd leg): 03/10/2021 20:00 | Winner: Atlético Cearense - CE | ||||
| 1st(1st leg) | S.E.R. Caxias - RS | - | União Rondonópolis - MT | 2:0 (1:0) | ||
| 2nd (2nd leg) | União Rondonópolis - MT | - | S.E.R. Caxias - RS | 0:2 (0:0) | ||
| 1st(1st leg): 25/09/2021 20:00 | 2nd (2nd leg): 02/10/2021 20:00 | Winner: S.E.R. Caxias - RS | ||||
| 1st(1st leg) | Campinense - PB | - | Guarany de Sobral - CE | 2:1 (1:1) | ||
| 2nd (2nd leg) | Guarany de Sobral - CE | - | Campinense - PB | 0:2 (0:0) | ||
| 1st(1st leg): 25/09/2021 20:00 | 2nd (2nd leg): 03/10/2021 19:00 | Winner: Campinense - PB | ||||
| 1st(1st leg) | Esportivo - RS | - | Ferroviária - SP | 1:2 (0:0) | ||
| 2nd (2nd leg) | Ferroviária - SP | - | Esportivo - RS | 1:1 (1:0) | ||
| 1st(1st leg): 25/09/2021 20:00 | 2nd (2nd leg): 03/10/2021 20:00 | Winner: Ferroviária - SP | ||||
| 1st(1st leg) | 4 de Julho - PI | - | ABC - RN | 1:1 (1:1) | ||
| 2nd (2nd leg) | ABC - RN | - | 4 de Julho - PI | 2:0 (1:0) | ||
| 1st(1st leg): 26/09/2021 19:00 | 2nd (2nd leg): 03/10/2021 20:00 | Winner: ABC - RN | ||||
| 1st(1st leg) | Uberlândia - MG | - | Joinville - SC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Joinville - SC | - | Uberlândia - MG | 1:3 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 26/09/2021 20:00 | 2nd (2nd leg): 02/10/2021 19:00 | Winner: Uberlândia - MG | ||||
| 1st(1st leg) | Cianorte - PR | - | Aparecidense - GO | 0:0 (0:0) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | Cianorte - PR | 1:0 (0:0) | ||
| 1st(1st leg): 26/09/2021 20:00 | 2nd (2nd leg): 02/10/2021 20:00 | Winner: Aparecidense - GO | ||||
| 1st(1st leg) | América - RN | - | Moto Club - MA | 1:0 (1:0) | ||
| 2nd (2nd leg) | Moto Club - MA | - | América - RN | 2:4 (0:2) | ||
| 1st(1st leg): 26/09/2021 20:00 | 2nd (2nd leg): 03/10/2021 19:00 | Winner: América - RN | ||||
