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| 1st(1st leg) | Santana - AP | - | GA Sampaio - RR | 1:2 (1:0) | ||
| 2nd (2nd leg) | GA Sampaio - RR | - | Santana - AP | 3:0 (2:0) | ||
| 1st(1st leg): 26/05/2021 19:00 | 2nd (2nd leg): 30/05/2021 21:00 | Winner: GA Sampaio - RR | ||||
| 1st(1st leg) | Tocantinópolis - TO | - | Picos - PI | 2:0 (1:0) | ||
| 2nd (2nd leg) | Picos - PI | - | Tocantinópolis - TO | 1:4 (1:0, 3:1, 3:1) pso | ||
| 1st(1st leg): 26/05/2021 20:00 | 2nd (2nd leg): 30/05/2021 20:00 | Winner: Tocantinópolis - TO | ||||
| 1st(1st leg) | Real Ariquemes - RO | - | Brasiliense - DF | 0:2 (0:0) | ||
| 2nd (2nd leg) | Brasiliense - DF | - | Real Ariquemes - RO | 3:1 (1:0) | ||
| 1st(1st leg): 26/05/2021 20:00 | 2nd (2nd leg): 30/05/2021 19:00 | Winner: Brasiliense - DF | ||||
| 1st(1st leg) | Aquidauanense - MS | - | Rio Branco - ES | 1:4 (1:3) | ||
| 2nd (2nd leg) | Rio Branco - ES | - | Aquidauanense - MS | 2:0 (0:0) | ||
| 1st(1st leg): 26/05/2021 20:00 | 2nd (2nd leg): 30/05/2021 22:00 | Winner: Rio Branco - ES | ||||
