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| 1st(1st leg) | Uberlândia - MG | - | Aparecidense - GO | 0:1 (0:0) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | Uberlândia - MG | 1:1 (0:0) | ||
| 1st(1st leg): 09/10/2021 19:00 | 2nd (2nd leg): 16/10/2021 19:00 | Winner: Aparecidense - GO | ||||
| 1st(1st leg) | América - RN | - | Campinense - PB | 0:0 (0:0) | ||
| 2nd (2nd leg) | Campinense - PB | - | América - RN | 4:2 (0:0, 0:0) pso | ||
| 1st(1st leg): 09/10/2021 21:30 | 2nd (2nd leg): 16/10/2021 21:30 | Winner: Campinense - PB | ||||
| 1st(1st leg) | Atlético Cearense - CE | - | Ferroviária - SP | 1:1 (1:1) | ||
| 2nd (2nd leg) | Ferroviária - SP | - | Atlético Cearense - CE | 3:4 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 10/10/2021 19:00 | 2nd (2nd leg): 17/10/2021 19:00 | Winner: Atlético Cearense - CE | ||||
| 1st(1st leg) | S.E.R. Caxias - RS | - | ABC - RN | 0:0 (0:0) | ||
| 2nd (2nd leg) | ABC - RN | - | S.E.R. Caxias - RS | 3:0 (0:0) | ||
| 1st(1st leg): 10/10/2021 21:30 | 2nd (2nd leg): 17/10/2021 21:30 | Winner: ABC - RN | ||||
