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| 1st(1st leg) | Palmeiras | - | Athletico Paranaense | 3:2 (2:1) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Palmeiras | 6:7 (2:3, 4:3, 4:3) pso | ||
| 1st(1st leg): 05/01/2021 19:00 | 2nd (2nd leg): 09/01/2021 17:00 | Winner: Palmeiras | ||||
| 1st(1st leg) | Sport Recife - PE | - | Flamengo RJ | 1:2 (1:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Sport Recife - PE | 2:1 (1:1) | ||
| 1st(1st leg): 06/01/2021 18:00 | 2nd (2nd leg): 10/01/2021 18:30 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | São Paulo FC | - | River - PI | 4:0 (2:0) | ||
| 2nd (2nd leg) | River - PI | - | São Paulo FC | 0:1 (0:1) | ||
| 1st(1st leg): 06/01/2021 19:00 | 2nd (2nd leg): 10/01/2021 19:00 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Atlético Mineiro | - | Fluminense RJ | 2:2 (1:0) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Atlético Mineiro | 4:1 (3:1) | ||
| 1st(1st leg): 06/01/2021 22:00 | 2nd (2nd leg): 10/01/2021 21:15 | Winner: Fluminense RJ | ||||
