1st(1st leg) Athletico Paranaense - CR Brasil - AL 3:0 (1:0)
2nd (2nd leg) CR Brasil - AL - Athletico Paranaense 2:1 (1:1)
1st(1st leg): 31/08/2021 19:00 2nd (2nd leg): 06/09/2021 19:00 Winner: Athletico Paranaense
1st(1st leg) Porto Vitória - ES - São Raimundo - RR 3:0 (0:0)
2nd (2nd leg) São Raimundo - RR - Porto Vitória - ES 1:2 (1:1)
1st(1st leg): 31/08/2021 19:00 2nd (2nd leg): 07/09/2021 21:00 Winner: Porto Vitória - ES
1st(1st leg) Jacuipense - BA - São Paulo FC 1:4 (0:2)
2nd (2nd leg) São Paulo FC - Jacuipense - BA 8:2 (7:0)
1st(1st leg): 31/08/2021 19:00 2nd (2nd leg): 07/09/2021 20:00 Winner: São Paulo FC
1st(1st leg) Criciúma - SC - Fluminense RJ 1:2 (0:1)
2nd (2nd leg) Fluminense RJ - Criciúma - SC 1:0 (0:0)
1st(1st leg): 31/08/2021 19:00 2nd (2nd leg): 07/09/2021 14:00 Winner: Fluminense RJ
1st(1st leg) Gama - DF - Flamengo RJ 0:4 (0:1)
2nd (2nd leg) Flamengo RJ - Gama - DF 6:0 (2:0)
1st(1st leg): 31/08/2021 19:30 2nd (2nd leg): 07/09/2021 14:00 Winner: Flamengo RJ
1st(1st leg) Palmeiras - Confiança - SE 10:0 (2:0)
2nd (2nd leg) Confiança - SE - Palmeiras 1:6 (1:2)
1st(1st leg): 31/08/2021 23:00 2nd (2nd leg): 08/09/2021 23:15 Winner: Palmeiras
1st(1st leg) Sport Recife - PE - Cruzeiro 2:2 (0:1)
2nd (2nd leg) Cruzeiro - Sport Recife - PE 3:1 (1:0)
1st(1st leg): 01/09/2021 01:30 2nd (2nd leg): 09/09/2021 01:30 Winner: Cruzeiro
1st(1st leg) Atlético Mineiro - Londrina - PR 4:2 (2:0)
2nd (2nd leg) Londrina - PR - Atlético Mineiro 1:2 (1:1)
1st(1st leg): 01/09/2021 20:00 2nd (2nd leg): 07/09/2021 19:00 Winner: Atlético Mineiro