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| 1st(1st leg) | Porto Vitória - ES | - | Atlético Mineiro | 0:5 (0:3) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Porto Vitória - ES | 7:0 (4:0) | ||
| 1st(1st leg): 21/09/2021 19:00 | 2nd (2nd leg): 28/09/2021 20:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Cruzeiro | - | Flamengo RJ | 0:0 (0:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Cruzeiro | 3:1 (1:1) | ||
| 1st(1st leg): 22/09/2021 20:00 | 2nd (2nd leg): 30/09/2021 23:00 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Palmeiras | - | Athletico Paranaense | 2:0 (2:0) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Palmeiras | 4:3 (2:1) | ||
| 1st(1st leg): 23/09/2021 19:00 | 2nd (2nd leg): 29/09/2021 19:00 | Winner: Palmeiras | ||||
| 1st(1st leg) | São Paulo FC | - | Fluminense RJ | 1:1 (1:0) | ||
| 2nd (2nd leg) | Fluminense RJ | - | São Paulo FC | 1:4 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 24/09/2021 01:30 | 2nd (2nd leg): 01/10/2021 23:00 | Winner: São Paulo FC | ||||
