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| 1st(1st leg) | Goiás - GO | - | Fluminense RJ | 2:4 (2:4) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Goiás - GO | 5:1 (3:0) | ||
| 1st(1st leg): 04/05/2022 19:00 | 2nd (2nd leg): 11/05/2022 19:00 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Bahia - BA | - | Londrina - PR | 3:0 (2:0) | ||
| 2nd (2nd leg) | Londrina - PR | - | Bahia - BA | 2:1 (1:0) | ||
| 1st(1st leg): 04/05/2022 19:00 | 2nd (2nd leg): 11/05/2022 19:00 | Winner: Bahia - BA | ||||
| 1st(1st leg) | Criciúma - SC | - | Fortaleza | 2:0 (0:0) | ||
| 2nd (2nd leg) | Fortaleza | - | Criciúma - SC | 4:0 (1:0) | ||
| 1st(1st leg): 04/05/2022 19:00 | 2nd (2nd leg): 11/05/2022 19:00 | Winner: Fortaleza | ||||
| 1st(1st leg) | Palmeiras | - | Remo - PA | 7:0 (1:0) | ||
| 2nd (2nd leg) | Remo - PA | - | Palmeiras | 1:4 (0:0) | ||
| 1st(1st leg): 04/05/2022 19:00 | 2nd (2nd leg): 12/05/2022 00:00 | Winner: Palmeiras | ||||
| 1st(1st leg) | Cruzeiro | - | Athletico Paranaense | 2:1 (1:0) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Cruzeiro | 2:2 (2:0) | ||
| 1st(1st leg): 04/05/2022 19:00 | 2nd (2nd leg): 11/05/2022 19:00 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Atlético Mineiro | - | Cuiabá - MT | 4:1 (3:0) | ||
| 2nd (2nd leg) | Cuiabá - MT | - | Atlético Mineiro | 2:9 (2:5) | ||
| 1st(1st leg): 04/05/2022 20:00 | 2nd (2nd leg): 11/05/2022 20:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Vasco da Gama | - | Internacional | 4:0 (2:0) | ||
| 2nd (2nd leg) | Internacional | - | Vasco da Gama | 1:3 (1:1) | ||
| 1st(1st leg): 05/05/2022 19:30 | 2nd (2nd leg): 09/05/2022 19:30 | Winner: Vasco da Gama | ||||
| 1st(1st leg) | Corinthians SP | - | Sport Recife - PE | 1:1 (1:1) | ||
| 2nd (2nd leg) | Sport Recife - PE | - | Corinthians SP | 1:0 (1:0) | ||
| 1st(1st leg): 05/05/2022 23:00 | 2nd (2nd leg): 10/05/2022 19:15 | Winner: Sport Recife - PE | ||||
