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| 1st(1st leg) | Sport Recife - PE | - | Cruzeiro | 2:1 (1:1) | ||
| 2nd (2nd leg) | Cruzeiro | - | Sport Recife - PE | 1:1 (1:1) | ||
| 1st(1st leg): 17/05/2022 19:30 | 2nd (2nd leg): 23/05/2022 19:30 | Winner: Sport Recife - PE | ||||
| 1st(1st leg) | Vasco da Gama | - | Fluminense RJ | 2:1 (1:0) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Vasco da Gama | 4:5 (1:0, 2:1, 2:1) pso | ||
| 1st(1st leg): 17/05/2022 23:00 | 2nd (2nd leg): 26/05/2022 01:30 | Winner: Vasco da Gama | ||||
| 1st(1st leg) | Atlético Mineiro | - | Palmeiras | 0:5 (0:2) | ||
| 2nd (2nd leg) | Palmeiras | - | Atlético Mineiro | 3:1 (0:1) | ||
| 1st(1st leg): 18/05/2022 19:30 | 2nd (2nd leg): 24/05/2022 23:00 | Winner: Palmeiras | ||||
| 1st(1st leg) | Bahia - BA | - | Fortaleza | 3:0 (2:0) | ||
| 2nd (2nd leg) | Fortaleza | - | Bahia - BA | 1:2 (1:1) | ||
| 1st(1st leg): 18/05/2022 23:00 | 2nd (2nd leg): 26/05/2022 23:00 | Winner: Bahia - BA | ||||
