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| 1st(1st leg) | Internacional | - | Atlético Mineiro | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Internacional | 0:1 (0:0) | ||
| 1st(1st leg): 31/10/2021 19:00 | 2nd (2nd leg): 07/11/2021 14:00 | Winner: Internacional | ||||
| 1st(1st leg) | São Paulo FC | - | Flamengo RJ | 1:0 (1:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | São Paulo FC | 1:1 (0:1) | ||
| 1st(1st leg): 01/11/2021 18:00 | 2nd (2nd leg): 05/11/2021 18:30 | Winner: São Paulo FC | ||||
