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| 1st(1st leg) | Botafogo - RJ | - | Atlético Mineiro | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Botafogo - RJ | 2:0 (1:0) | ||
| 1st(1st leg): 17/10/2021 20:00 | 2nd (2nd leg): 22/10/2021 20:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Internacional | - | Palmeiras | 2:1 (0:1) | ||
| 2nd (2nd leg) | Palmeiras | - | Internacional | 3:3 (2:1) | ||
| 1st(1st leg): 18/10/2021 19:00 | 2nd (2nd leg): 24/10/2021 14:30 | Winner: Internacional | ||||
| 1st(1st leg) | Athletico Paranaense | - | São Paulo FC | 1:1 (0:1) | ||
| 2nd (2nd leg) | São Paulo FC | - | Athletico Paranaense | 3:2 (1:0) | ||
| 1st(1st leg): 18/10/2021 21:00 | 2nd (2nd leg): 25/10/2021 20:00 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Vasco da Gama | - | Flamengo RJ | 2:1 (1:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Vasco da Gama | 3:0 (1:0) | ||
| 1st(1st leg): 20/10/2021 21:00 | 2nd (2nd leg): 26/10/2021 19:15 | Winner: Flamengo RJ | ||||
