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| 1st(1st leg) | Tupi - MG | - | Internacional | 1:4 (0:2) | ||
| 2nd (2nd leg) | Internacional | - | Tupi - MG | 5:0 (1:0) | ||
| 1st(1st leg): 04/05/2021 23:00 | 2nd (2nd leg): 07/05/2021 23:00 | Winner: Internacional | ||||
| 1st(1st leg) | ABC - RN | - | Avai - SC | 0:3 (0:0) | ||
| 2nd (2nd leg) | Avai - SC | - | ABC - RN | 0:3 (0:3) | ||
| 1st(1st leg): 05/05/2021 19:00 | 2nd (2nd leg): 09/05/2021 10:00 | |||||
| 1st(1st leg) | Botafogo - RJ | - | São José - RS | 2:0 (1:0) | ||
| 2nd (2nd leg) | São José - RS | - | Botafogo - RJ | 1:1 (1:1) | ||
| 1st(1st leg): 05/05/2021 19:00 | 2nd (2nd leg): 09/05/2021 19:00 | Winner: Botafogo - RJ | ||||
| 1st(1st leg) | Coritiba - PR | - | Bahia - BA | 1:0 (1:0) | ||
| 2nd (2nd leg) | Bahia - BA | - | Coritiba - PR | 2:2 (2:2) | ||
| 1st(1st leg): 05/05/2021 19:00 | 2nd (2nd leg): 10/05/2021 19:00 | Winner: Coritiba - PR | ||||
| 1st(1st leg) | CEU - MS | - | Floresta - CE | 1:2 (0:1) | ||
| 2nd (2nd leg) | Floresta - CE | - | CEU - MS | 5:0 (3:0) | ||
| 1st(1st leg): 05/05/2021 20:00 | 2nd (2nd leg): 12/05/2021 13:30 | Winner: Floresta - CE | ||||
| 1st(1st leg) | São Raimundo - RR | - | Vasco da Gama | 1:3 (0:3) | ||
| 2nd (2nd leg) | Vasco da Gama | - | São Raimundo - RR | 4:2 (2:0) | ||
| 1st(1st leg): 05/05/2021 21:00 | 2nd (2nd leg): 09/05/2021 19:00 | Winner: Vasco da Gama | ||||
| 1st(1st leg) | Atlético Mineiro | - | Galvez - AC | 5:0 (1:0) | ||
| 2nd (2nd leg) | Galvez - AC | - | Atlético Mineiro | 2:2 (0:2) | ||
| 1st(1st leg): 05/05/2021 21:00 | 2nd (2nd leg): 09/05/2021 23:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Palmeiras | - | Náutico - PE | 4:0 (3:0) | ||
| 2nd (2nd leg) | Náutico - PE | - | Palmeiras | 1:2 (1:2) | ||
| 1st(1st leg): 06/05/2021 00:00 | 2nd (2nd leg): 09/05/2021 20:00 | Winner: Palmeiras | ||||
