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| 01/04/2022 | 19:30 | 1. FC Union Berlin | - | 1. FC Köln | 1:0 (0:0) | |
| 02/04/2022 | 14:30 | SC Freiburg | - | Bayern München | 1:4 (0:0) | |
| 14:30 | Arminia Bielefeld | - | VfB Stuttgart | 1:1 (0:1) | ||
| 14:30 | Bayer Leverkusen | - | Hertha BSC | 2:1 (2:1) | ||
| 14:30 | 1899 Hoffenheim | - | VfL Bochum | 1:2 (0:1) | ||
| 14:30 | Eintracht Frankfurt | - | SpVgg Greuther Fürth | 0:0 (0:0) | ||
| 17:30 | Borussia Dortmund | - | RB Leipzig | 1:4 (0:2) | ||
| 03/04/2022 | 14:30 | FC Augsburg | - | VfL Wolfsburg | 3:0 (1:0) | |
| 16:30 | Bor. Mönchengladbach | - | 1. FSV Mainz 05 | 1:1 (1:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 28 | 21 | 3 | 4 | 85:29 | 56 | 66 |
| 2 |
|
Borussia Dortmund | 28 | 18 | 3 | 7 | 68:42 | 26 | 57 |
| 3 |
|
Bayer Leverkusen | 28 | 15 | 6 | 7 | 68:42 | 26 | 51 |
| 4 |
|
RB Leipzig | 28 | 14 | 6 | 8 | 61:31 | 30 | 48 |
| 5 |
|
SC Freiburg | 28 | 12 | 9 | 7 | 44:33 | 11 | 45 |
| 6 |
|
1899 Hoffenheim | 28 | 13 | 5 | 10 | 50:42 | 8 | 44 |
| 7 |
|
1. FC Union Berlin | 28 | 11 | 8 | 9 | 34:38 | -4 | 41 |
| 8 |
|
1. FC Köln | 28 | 10 | 10 | 8 | 38:41 | -3 | 40 |
| 9 |
|
Eintracht Frankfurt | 28 | 10 | 9 | 9 | 39:38 | 1 | 39 |
| 10 |
|
1. FSV Mainz 05 | 28 | 11 | 5 | 12 | 41:33 | 8 | 38 |
| 11 |
|
VfL Bochum | 28 | 10 | 5 | 13 | 30:40 | -10 | 35 |
| 12 |
|
Bor. Mönchengladbach | 28 | 9 | 7 | 12 | 39:52 | -13 | 34 |
| 13 |
|
FC Augsburg | 28 | 8 | 8 | 12 | 34:45 | -11 | 32 |
| 14 |
|
VfL Wolfsburg | 28 | 9 | 4 | 15 | 29:45 | -16 | 31 |
| 15 |
|
VfB Stuttgart | 28 | 6 | 9 | 13 | 36:51 | -15 | 27 |
| 16 |
|
Arminia Bielefeld | 28 | 5 | 11 | 12 | 23:39 | -16 | 26 |
| 17 |
|
Hertha BSC | 28 | 7 | 5 | 16 | 30:62 | -32 | 26 |
| 18 |
|
SpVgg Greuther Fürth | 28 | 3 | 7 | 18 | 24:70 | -46 | 16 |
| Champions League | |
| Europa League | |
| Playoffs | |
| Relegation |
