1st(1st leg) JS Kabylie - Ashanti Gold 3:0
2nd (2nd leg) Ashanti Gold - JS Kabylie 0:0
1st(1st leg): 21/03/2008 15:00 2nd (2nd leg): 06/04/2008 Winner: JS Kabylie
1st(1st leg) Sporting Praia - GD Interclube 2:1
2nd (2nd leg) GD Interclube - Sporting Praia 1:0
1st(1st leg): 22/03/2008 2nd (2nd leg): 06/04/2008 17:00 Winner: GD Interclube
1st(1st leg) Mamelodi Sundowns - Curepipe Starlight SC 3:0
2nd (2nd leg) Curepipe Starlight SC - Mamelodi Sundowns 0:1
1st(1st leg): 22/03/2008 2nd (2nd leg): 05/04/2008 Winner: Mamelodi Sundowns
1st(1st leg) Platinum Stars - US Stade Tamponnaise 2:0
2nd (2nd leg) US Stade Tamponnaise - Platinum Stars 0:1
1st(1st leg): 22/03/2008 2nd (2nd leg): 05/04/2008 17:00 Winner: Platinum Stars
1st(1st leg) Olympique de Khouribga - ES Sétif 2:0
2nd (2nd leg) ES Sétif - Olympique de Khouribga 0:3 pso
1st(1st leg): 22/03/2008 15:25 2nd (2nd leg): 06/04/2008 19:00 Winner: Olympique de Khouribga
1st(1st leg) Étoile du Sahel - AS Douanes 5:0
2nd (2nd leg) AS Douanes - Étoile du Sahel 3:0
1st(1st leg): 22/03/2008 16:00 2nd (2nd leg): 05/04/2008 Winner: Étoile du Sahel
1st(1st leg) ASEC Mimosas - AS Kaloum Star 1:1
2nd (2nd leg) AS Kaloum Star - ASEC Mimosas 0:1
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 06/04/2008 15:30 Winner: ASEC Mimosas
1st(1st leg) Al Hilal Omdurman - ZESCO United 2:0
2nd (2nd leg) ZESCO United - Al Hilal Omdurman 1:1
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 05/04/2008 19:30 Winner: Al Hilal Omdurman
1st(1st leg) Zamalek - Africa Sports 2:0
2nd (2nd leg) Africa Sports - Zamalek 4:5 pso
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 06/04/2008 16:30 Winner: Zamalek
1st(1st leg) Dynamos - Ajesaia 3:0
2nd (2nd leg) Ajesaia - Dynamos 2:1
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 05/04/2008 Winner: Dynamos
1st(1st leg) Coton Sport Garoua - Gombe United 5:0
2nd (2nd leg) Gombe United - Coton Sport Garoua 2:1
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 06/04/2008 15:00 Winner: Coton Sport Garoua
1st(1st leg) ASKO Kara - Club Africain 2:0
2nd (2nd leg) Club Africain - ASKO Kara 4:0
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 04/04/2008 15:00 Winner: Club Africain
1st(1st leg) Enyimba Aba - Simba SC 4:0
2nd (2nd leg) Simba SC - Enyimba Aba 1:3
1st(1st leg): 23/03/2008 17:00 2nd (2nd leg): 05/04/2008 Winner: Enyimba Aba
1st(1st leg) Al Ittihad Tripolis - CD 1º de Agosto 1:0
2nd (2nd leg) CD 1º de Agosto - Al Ittihad Tripolis 2:1
1st(1st leg): 23/03/2008 18:00 2nd (2nd leg): 04/04/2008 15:30 Winner: Al Ittihad Tripolis
1st(1st leg) TP Mazembe - FC 105 Libreville 1:1
2nd (2nd leg) FC 105 Libreville - TP Mazembe 0:1
1st(1st leg): 23/03/2008 18:00 2nd (2nd leg): 05/04/2008 Winner: TP Mazembe