1st(1st leg) Young Africans - Zamalek 1:1 (1:0)
2nd (2nd leg) Zamalek - Young Africans 1:0 (1:0)
1st(1st leg): 18/02/2012 13:00 2nd (2nd leg): 03/03/2012 16:00 Winner: Zamalek
1st(1st leg) Coin Nord Mitsamiouli - Ethiopian Coffee 1:0 (1:0)
2nd (2nd leg) Ethiopian Coffee - Coin Nord Mitsamiouli 4:1 (1:0)
1st(1st leg): 18/02/2012 13:00 2nd (2nd leg): 04/03/2012 13:00 Winner: Ethiopian Coffee
1st(1st leg) URA SC - LCS 3:0 (1:0)
2nd (2nd leg) LCS - URA SC 0:0 (0:0)
1st(1st leg): 18/02/2012 13:00 2nd (2nd leg): 04/03/2012 14:00 Winner: URA SC
1st(1st leg) Tusker FC - APR FC 0:0 (0:0)
2nd (2nd leg) APR FC - Tusker FC 1:0 (0:0)
1st(1st leg): 18/02/2012 13:00 2nd (2nd leg): 04/03/2012 13:30 Winner: APR FC
1st(1st leg) Foullah Edifice - JSM Béjaïa 0:0 (0:0)
2nd (2nd leg) JSM Béjaïa - Foullah Edifice 3:1 (2:0)
1st(1st leg): 18/02/2012 14:00 2nd (2nd leg): 02/03/2012 15:00 Winner: JSM Béjaïa
1st(1st leg) AS GNN Niamey - Tonnerre d'Abomey 0:0 (0:0)
2nd (2nd leg) Tonnerre d'Abomey - AS GNN Niamey 1:0 (0:0)
1st(1st leg): 18/02/2012 14:30 2nd (2nd leg): 04/03/2012 15:00 Winner: Tonnerre d'Abomey
1st(1st leg) ASFA Yennenga - ASO Chlef 0:0 (0:0)
2nd (2nd leg) ASO Chlef - ASFA Yennenga 4:1 (1:1)
1st(1st leg): 18/02/2012 16:00 2nd (2nd leg): 02/03/2012 17:00 Winner: ASO Chlef
1st(1st leg) Ports Authority - Horoya AC 0:0 (0:0)
2nd (2nd leg) Horoya AC - Ports Authority 1:0 (0:0)
1st(1st leg): 18/02/2012 16:00 2nd (2nd leg): 04/03/2012 16:00 Winner: Horoya AC
1st(1st leg) Brikama United - US Ouakam 0:1 (0:0)
2nd (2nd leg) US Ouakam - Brikama United 1:3 (0:0, 0:1, 0:1) pso
1st(1st leg): 18/02/2012 16:30 2nd (2nd leg): 03/03/2012 16:30 Winner: Brikama United
1st(1st leg) Japan Actuel's - Power Dynamos 1:5 (0:1)
2nd (2nd leg) Power Dynamos - Japan Actuel's 3:0 (3:0)
1st(1st leg): 19/02/2012 12:00 2nd (2nd leg): 04/03/2012 14:00 Winner: Power Dynamos
1st(1st leg) Orlando Pirates - CRD Libolo 1:3 (0:2)
2nd (2nd leg) CRD Libolo - Orlando Pirates 1:1 (1:1)
1st(1st leg): 19/02/2012 13:00 2nd (2nd leg): 03/03/2012 14:00 Winner: CRD Libolo
1st(1st leg) DFC 8ème - Les Astres FC 1:0 (0:0)
2nd (2nd leg) Les Astres FC - DFC 8ème 2:1 (0:0)
1st(1st leg): 19/02/2012 14:00 2nd (2nd leg): 04/03/2012 14:00 Winner: DFC 8ème
1st(1st leg) Missiles FC - Africa Sports 3:2 (3:2)
2nd (2nd leg) Africa Sports - Missiles FC 2:0 (1:0)
1st(1st leg): 19/02/2012 14:30 2nd (2nd leg): 04/03/2012 15:30 Winner: Africa Sports
1st(1st leg) Green Mamba FC - FC Platinum 2:4 (0:3)
2nd (2nd leg) FC Platinum - Green Mamba FC 4:0 (4:0)
1st(1st leg): 19/02/2012 15:00 2nd (2nd leg): 03/03/2012 14:00 Winner: FC Platinum
1st(1st leg) Sony de Elá Nguema - Dolphins FC 0:3 (0:2)
2nd (2nd leg) Dolphins FC - Sony de Elá Nguema 3:0 (2:0)
1st(1st leg): 19/02/2012 15:00 2nd (2nd leg): 04/03/2012 14:00 Winner: Dolphins FC
1st(1st leg) AFAD Djékanou - Diables Noirs 1:0 (0:0)
2nd (2nd leg) Diables Noirs - AFAD Djékanou 0:1 (0:0)
1st(1st leg): 19/02/2012 15:30 2nd (2nd leg): 06/03/2012 14:30 Winner: AFAD Djékanou
1st(1st leg) LISCR FC - Berekum Chelsea 0:2 (0:0)
2nd (2nd leg) Berekum Chelsea - LISCR FC 3:0 (1:0)
1st(1st leg): 19/02/2012 16:00 2nd (2nd leg): 04/03/2012 15:00 Winner: Berekum Chelsea
1st(1st leg) Mafunzo - Liga Muçulmana 0:2 (0:2)
2nd (2nd leg) Liga Muçulmana - Mafunzo 3:0 (2:0)
1st(1st leg): 19/02/2012 18:30 2nd (2nd leg): 10/03/2012 13:00 Winner: Liga Muçulmana
1st(1st leg) AS Vita Club - Atletico Olympique FC 5:0 (3:0)
2nd (2nd leg) Atletico Olympique FC - AS Vita Club 4:1 (2:1)
1st(1st leg): 10/03/2012 14:30 2nd (2nd leg): 18/03/2012 13:00 Winner: AS Vita Club