1st(1st leg) Young Africans - Township Rollers FC 1:2 (1:1)
2nd (2nd leg) Township Rollers FC - Young Africans 0:0 (0:0)
1st(1st leg): 06/03/2018 13:30 2nd (2nd leg): 17/03/2018 13:45 Winner: Township Rollers FC
1st(1st leg) Horoya AC - AS Génération Foot 2:1 (0:0)
2nd (2nd leg) AS Génération Foot - Horoya AC 0:2 (0:1)
1st(1st leg): 06/03/2018 17:00 2nd (2nd leg): 17/03/2018 17:30 Winner: Horoya AC
1st(1st leg) Étoile du Sahel - Plateau United 4:2 (3:0)
2nd (2nd leg) Plateau United - Étoile du Sahel 1:0 (1:0)
1st(1st leg): 06/03/2018 17:00 2nd (2nd leg): 18/03/2018 13:00 Winner: Étoile du Sahel
1st(1st leg) Al Ahly SC - CF Mounana 4:0 (2:0)
2nd (2nd leg) CF Mounana - Al Ahly SC 1:3 (1:2)
1st(1st leg): 06/03/2018 18:00 2nd (2nd leg): 17/03/2018 14:30 Winner: Al Ahly SC
1st(1st leg) Gor Mahia FC - Espérance de Tunis 0:0 (0:0)
2nd (2nd leg) Espérance de Tunis - Gor Mahia FC 1:0 (1:0)
1st(1st leg): 07/03/2018 12:00 2nd (2nd leg): 18/03/2018 15:00 Winner: Espérance de Tunis
1st(1st leg) St. George SC - KCCA FC 0:0 (0:0)
2nd (2nd leg) KCCA FC - St. George SC 1:0 (0:0)
1st(1st leg): 07/03/2018 13:00 2nd (2nd leg): 17/03/2018 13:00 Winner: KCCA FC
1st(1st leg) Zanaco FC - Mbabane Swallows 1:2 (1:0)
2nd (2nd leg) Mbabane Swallows - Zanaco FC 1:0 (1:0)
1st(1st leg): 07/03/2018 13:00 2nd (2nd leg): 17/03/2018 13:00 Winner: Mbabane Swallows
1st(1st leg) ZESCO United - ASEC Mimosas 0:1 (0:1)
2nd (2nd leg) ASEC Mimosas - ZESCO United 1:2 (1:1)
1st(1st leg): 07/03/2018 13:00 2nd (2nd leg): 18/03/2018 16:00 Winner: ZESCO United
1st(1st leg) TP Mazembe - UD Songo 4:0 (1:0)
2nd (2nd leg) UD Songo - TP Mazembe 3:0 (1:0)
1st(1st leg): 07/03/2018 13:30 2nd (2nd leg): 17/03/2018 13:00 Winner: TP Mazembe
1st(1st leg) Aduana Stars - ES Sétif 1:0 (0:0)
2nd (2nd leg) ES Sétif - Aduana Stars 4:0 (2:0)
1st(1st leg): 07/03/2018 15:00 2nd (2nd leg): 18/03/2018 18:00 Winner: ES Sétif
1st(1st leg) MFM FC - MC Alger 2:1 (1:0)
2nd (2nd leg) MC Alger - MFM FC 6:0 (4:0)
1st(1st leg): 07/03/2018 15:00 2nd (2nd leg): 17/03/2018 19:45 Winner: MC Alger
1st(1st leg) AS Togo-Port - Al Hilal Omdurman 2:0 (1:0)
2nd (2nd leg) Al Hilal Omdurman - AS Togo-Port 3:1 (1:1)
1st(1st leg): 07/03/2018 15:00 2nd (2nd leg): 18/03/2018 17:30 Winner: AS Togo-Port
1st(1st leg) CD 1º de Agosto - BidVest Wits 1:0 (0:0)
2nd (2nd leg) BidVest Wits - CD 1º de Agosto 2:3 (0:0, 1:0) pso
1st(1st leg): 07/03/2018 15:00 2nd (2nd leg): 17/03/2018 15:00 Winner: CD 1º de Agosto
1st(1st leg) Rayon Sports - Mamelodi Sundowns 0:0 (0:0)
2nd (2nd leg) Mamelodi Sundowns - Rayon Sports 2:0 (1:0)
1st(1st leg): 07/03/2018 16:00 2nd (2nd leg): 18/03/2018 17:00 Winner: Mamelodi Sundowns
1st(1st leg) Wydad AC - Williamsville AC 7:2 (2:2)
2nd (2nd leg) Williamsville AC - Wydad AC 2:0 (1:0)
1st(1st leg): 07/03/2018 18:00 2nd (2nd leg): 17/03/2018 16:00 Winner: Wydad AC
1st(1st leg) Difaâ d'el Jadida - AS Vita Club 1:0 (1:0)
2nd (2nd leg) AS Vita Club - Difaâ d'el Jadida 2:2 (1:0)
1st(1st leg): 07/03/2018 20:00 2nd (2nd leg): 18/03/2018 13:30 Winner: Difaâ d'el Jadida